9.25 Evaluation of Appropriateness of Left Ventricular Mass in a Paediatric Population with Obesity
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High Blood Press Cardiovasc Prev 2008; 15 (3): 171-215 1120-9879/08/0003-0171/$48.00/0 © 2008 Adis Data Information BV. All rights reserved.
Metabolic Aspects and Mechanisms 9.25 Evaluation of Appropriateness of Left Ventricular Mass in a Paediatric Population with Obesity G. Tocci (1), A. Ferrucci (1), F. Ianniello (2), M. Evangelisti (2), A. Alterio (2), S. Sciarretta (1), F. Paneni (1), A. Macari (2), G.M. Ciavarella (1), L. De Biase (1), M.P. Villa (2), M. Volpe (1) ` di Roma “La Sapienza”, II Facolta ` Medicina, (1)UOC Cardiologia, Universita ` di Roma “La Sapienza”, II Facolta ` Medicina, Roma; (2)UOC Pediatria, Universita Roma, Italy Introduction. Recent studies demonstrated that the value of Left Ventricular Mass (LVM) which exceeds the individual haemodynamic workload (inappropriate LVM) may contribute to identify those subjects at high cardiovascular risk in adulthood. Aim. To evaluate the prevalence of inappropriate LVM in a paediatric population with obesity and in otherwise healthy normal-weight control subjects. Methods. A total of 106 individuals with paediatric obesity (39F and 67M, mean age 11,3 ± 3,0 years, BMI 27,5± 5,1, clinic BP levels 110,9±9,1/7 1,0±7,3 mmHg) and 53 control subjects (27M and 26F, mean age 11,1± 4,6 years, BMI 19,3±2,8, clinic BP levels 109,0±11,4/69,8± 8,9 mmHg) has been consecutively enrolled from September 2005 to December 2007. Obesity was defined as a Body Mass Index (BMI) over 90° percentile according for age and gender. All subjects underwent to complete physical examination, 2D-echocardiography and clinic and ambulatory BP measurements. In particular, LVM indexed by body surface area (LVMi), by height (LVMh) and height^2.7 (LVMh^2.7) were evaluated. The appropriateness of LVM to cardiac workload may be calculated by the ratio of observed LVM (oLVM) to the value predicted (pLVM) for an individual’s sex, height, and stroke work at rest. Results. LVM was higher in paediatric obese than in normal weight control subjects (98,4± 33,1 vs. 85,7±41,6gr; P=0,057). No significant differences were observed between these groups with respect to LVMi (62,7± 11,6 vs. 61,4±15,3 g/m2; P=0,58), while LVMh (65,5±17,0 vs. 55,9±19,6 g/m;P=0,004) and LVMH^2.7 (33,8±7,4 vs. 28,8±6,6 g/m^2.7; P
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