Impact of left ventricular volume and mass indexation method on the influence of obesity in a free-living population
- PDF / 409,673 Bytes
- 2 Pages / 610 x 792 pts Page_size
- 72 Downloads / 159 Views
BioMed Central
Open Access
Impact of left ventricular volume and mass indexation method on the influence of obesity in a free-living population
Michael L Chuang*1, Philimon Gona2, Carol J Salton1, Susan B Yeon1, Susan J Blease3, Daniel Levy3, Christopher J O'Donnell3 and Warren J Manning1 Address: 1Beth Israel Deaconess Medical Center, Boston, MA, USA, 2Department of Mathematics and Statistics, Boston University, Boston, MA, USA and 3the NHLBI's Framingham Heart Study, Framingham, MA, USA * Corresponding author
from 13th Annual SCMR Scientific Sessions Phoenix, AZ, USA. 21-24 January 2010 Published: 21 January 2010 Journal of Cardiovascular Magnetic Resonance 2010, 12(Suppl 1):P166
doi:10.1186/1532-429X-12-S1-P166
Abstracts of the 13th Annual SCMR Scientific Sessions - 2010
Meeting abstracts - A single PDF containing all abstracts in this Supplement is available here. http://www.biomedcentral.com/content/files/pdf/1532-429X-11-S1-infoThis abstract is available from: http://jcmr-online.com/content/12/S1/P166 © 2010 Chuang et al; licensee BioMed Central Ltd.
Introduction Increased left ventricular (LV) volume and mass are risk factors for increased cardiovascular disease. To account for differences in body size, LV parameters are generally indexed to height (HT) or body surface area (BSA). Increased body mass index (BMI), a measure of obesity, seems associated with increased LV volume and mass, but obesity is also associated with hypertension, potentially confounding relationships between BMI and LV volume and mass.
Purpose We sought to determine the impact of indexation method on relationship between LV volume and mass and adiposity, i.e., overweight (OW, BMI 25.0-29.9 kg/m2), obese (OB, BMI ≥30) versus normal weight (NL, BMI 18.5-24.9) in a never-hypertensive population.
Methods A subsample of 1794 members of the Framingham Heart Study Offspring cohort underwent CMR. Breath hold cine SSFP (TR3.0/TE1.5/FA 60°/1.56 × 1.92-mm2/THK 10mm/0 gap) was used to encompass the LV in the shortaxis orientation. LV contours were traced at end-diastole and end-systole to determine LV volumes (EDV, ESV) and mass. Offspring members have undergone comprehensive physical examinations every 3-4 years since 1971. Only Offspring free of hypertension (SBP≤140, DBP≤90 mmHg) on all examinations who never took antihypertensive medications were included in analysis. LV vol-
umes and mass were indexed to HT and BSA. Sex-specific comparison of raw and indexed LV volumes and mass among NL, OW and OB groups used generalized linear models with multivariate correction for clinical covariates (blood pressure, cholesterol, age, fasting glucose).
Results Of the 1794 Offspring scanned, 820 (50.2%) were never hypertensive. Men (n = 319) had significantly greater LV EDV, ESV and mass than women (n = 501) in each BMI category regardless of method of indexation (p < 0.01 all comparisons). The Table shows that in women EDV, ESV and mass, raw and indexed to HT, increased with greater BMI category (p for trend < 0.02 for all). In men mas
Data Loading...
