A Bifunctional Coordination Polymer for Al 3+ Ion Detection and its Treatment Effect on Nonalcoholic Fatty Liver Disease
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ORIGINAL ARTICLE
A Bifunctional Coordination Polymer for Al3+ Ion Detection and its Treatment Effect on Nonalcoholic Fatty Liver Disease by Promoting Lipoxygenases and Reducing Intrahepatic Triglyceride Content Ji-Jun Zhang 1 & Jie-Peng Jia 1 & Quan Shao 1 & Miaojuan Wang 2 & Jingyuan Wang 2 Received: 10 July 2020 / Accepted: 14 October 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract In this study, a new Cd(II)-bearing coordination polymer with the chemical formula of {[Cd4(meda)3(dpe)4(H2O)4]·(NO3)2· 2(H2O)}n (1, H2meda = 3,3′-methylenedibenzoic acid, dpe = 1,2-di(pyridin-4-yl)ethane) has been successfully prepared by reaction of Cd(NO3)·4H2O with a V-shape carboxyl ligand H2meda along with the linear dipyridine ligand dpe under the hydrothermal conditions. Due to its intensive luminescence, complex 1 could be utilized as the sensor of detecting Al3+ ion, and its detection limit is 4 × 10−6 M. Firstly, the toxicity of the compound on the normal liver cells was determined with Cell Counting Kit-8 detection kit. The triglyceride in liver cells was detected by detection kit after compound treatment and the relative expression of 15-lox and 12-lox in L02 cells was also measured by RT-PCR after compound treatment. In addition, multiple functional groups that provided by the synthesized Cd(II) complex have been studied by using molecular docking simulation for the confirmation of possible binding modes that formed between ligand and receptor. Keywords Coordination polymer . Mixed-ligand . Cd(II)-complex . Luminescent sensor . Liver cell . Molecular docking
Introduction Non-alcoholic fatty liver disease (NAFLD) refers to the lipid droplets excessive accumulation in the liver. It is known as a series of pathologies related to abnormal accumulation of liver fat [1, 2]. According to the recent reports NAFLD is the most common and top cause of liver disease in the United States, which affects almost to a third of the total population, causing a heavy burden for the people [3]. At beginning, NAFL is reversible and histopathologically related to significantly increased levels of lobular inflammation, and balloon injury [4].
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10895-020-02636-6) contains supplementary material, which is available to authorized users. * Quan Shao [email protected] 1
Department of General Surgery, Sixth Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
2
Department of Medical Center, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China
Further progression of the NAFLD with ongoing inflammation will lead to fibrosis and cirrhosis. Now, more and more researches begin to study the function of lipoxygenases in the liver. A new research about metabolomics in NASH patients showed that the production of lipoxygenase pathway products increases, which indicating an abnormal activity about lipoxygenases in the liver, the most well studied enzymes are 15-LOX and 12-LOX [5, 6]. The diversity of fat ty
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