A cohort study of personal and family history of skin cancer in relation to all-cause and cancer-specific mortality
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ORIGINAL PAPER
A cohort study of personal and family history of skin cancer in relation to all‑cause and cancer‑specific mortality James Small1 · Kristin Wallace2 · Elizabeth G. Hill3 · Bruce H. Thiers4 · Brian C. Leach5 · Anthony J. Alberg6 Received: 10 February 2020 / Accepted: 14 October 2020 © Springer Nature Switzerland AG 2020
Abstract Purpose Even though the fatality rate from skin cancers is low, evidence from a few cohort studies has raised the possibility that people with a personal history of skin cancer may have a higher all-cause mortality rate compared with those without a personal history of skin cancer. The purpose of the present study was to investigate the potential links between a personal history or family history of skin cancer and all-cause and cancer-specific mortality Methods A prospective cohort (n = 8,622) was assembled within the NHANES I follow-up study. Cox Proportional Hazard Regression analysis was used to estimate the hazard ratios (HR) and 95% confidence intervals (CI) for the association for personal and family history of skin cancer and all-cause and cancer-specific mortality. Results After adjustment for several potential confounding variables, a personal history of skin cancer was associated with decreased risk for all-cause mortality (HR 0.72, 95% CI 0.61–0.85), whereas the results for cancer-specific mortality were consistent with a null association (HR 0.97, 95% CI 0.74–1.27). A family history of skin cancer was not significantly associated with all-cause mortality (HR 0.97, 95% CI 0.76–1.24) or cancer-specific mortality (HR 0.69, 95% CI 0.38–1.24). Conclusion The results of the present study do not support the hypothesis that a personal history or family history of skin cancer is associated with an increased risk of all-cause or cancer-specific mortality. The high prevalence of skin cancer adds to the public health significance of this question, providing a strong rationale for further research to resolve this question. Keywords Personal history of skin cancer · Family history of skin cancer · Cohort · All-cause mortality · Cancer-specific mortality
Introduction Skin cancer is the most common form of cancer in the United States with its two most common subtypes, keratinocyte carcinoma (KC) and melanoma, accounting for, respectively, Electronic supplementary material The online version of this article (https://doi.org/10.1007/s10552-020-01359-0) contains supplementary material, which is available to authorized users. * Kristin Wallace [email protected] 1
Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC 29425, USA
2
Department of Public Health Sciences, Medical University of South Carolina, BE 103, 68 President Street, Charleston, SC 29425, USA
3
Department of Public Health Sciences, Medical University of South Carolina, 86 Jonathan Lucas St, Charleston, SC 29425, USA
2 million and 87,110 incident cases every year [1–3]. Even though the mortality rates are low for KC (0.69 deaths per 100,000 per year) and me
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