A comparative study using dual-energy X-ray absorptiometry, air displacement plethysmography, and skinfolds to assess fa
- PDF / 461,734 Bytes
- 9 Pages / 595.276 x 790.866 pts Page_size
- 42 Downloads / 148 Views
ORIGINAL ARTICLE
A comparative study using dual-energy X-ray absorptiometry, air displacement plethysmography, and skinfolds to assess fat mass in preterms at term equivalent age Dana F. J. Yumani 1
&
Dide de Jongh 2 & Harrie N. Lafeber 1 & Mirjam M. van Weissenbruch 1
Received: 12 July 2020 / Revised: 27 August 2020 / Accepted: 14 September 2020 # The Author(s) 2020
Abstract The aim of this study was to compare whole body composition, generated by air displacement plethysmography (ADP) and dualenergy X-ray absorptiometry (DXA), and to evaluate the potential predictive value of the sum of skinfolds (∑SFT) for whole body composition, in preterm infants at term equivalent age. A convenience sample of sixty-five preterm infants with a mean (SD) gestational age of 29 (1.6) weeks was studied at term equivalent age. Fat mass measured by DXA and ADP were compared and the ability of the ∑SFT to predict whole body fat mass was investigated. There was poor agreement between fat mass percentage measured with ADP compared with DXA (limits of agreement: − 4.8% and 13.7%). A previously modeled predictive equation with the ∑SFT as a predictor for absolute fat mass could not be validated. Corrected for confounders, the ∑SFT explained 42% (ADP, p = 0.001) and 75% (DXA, p = 0.001) of the variance in fat mass percentage. Conclusions: The ∑SFT was not able to accurately predict fat mass and ADP and DXA did not show comparable results. It remains to be elucidated whether or not DXA provides more accurate assessment of whole body fat mass than ADP in preterm infants. Trial registration: NTR5311
What is Known: • Diverse methods are used to assess fat mass in preterm infants. What is New: • This study showed that there is poor agreement between dual-energy X-ray absorptiometry, air displacement plethysmography, and skinfold thickness measurements. • Our results affirm the need for consensus guidelines on how to measure fat mass in preterm infants, to improve the assimilation of data from different studies and the implementation of the findings from those studies.
Communicated by Daniele De Luca * Dana F. J. Yumani [email protected] Dide de Jongh [email protected] Harrie N. Lafeber [email protected] Mirjam M. van Weissenbruch [email protected] 1
Department of Pediatrics, Amsterdam UMC, Location VU University Medical Center, De Boelelaan 1117, 1081, HV Amsterdam, The Netherlands
2
Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Eur J Pediatr
Keywords Fat mass . Dual-energy X-ray absorptiometry . Air displacement plethysmography . Skinfold thickness . Premature infants
Abbreviations ADP Air displacement plethysmography DXA Dual-energy X-ray PMA Postmenstrual age SDS Standard deviation score SGA Small for gestational age
Introduction Preterm infants are prone to develop risk factors for the metabolic syndrome in later life [1]. Adolescents and adults born preterm have been shown to have a higher fat mass, a higher blood pressure, and an increased risk of dysgly
Data Loading...
