A miR-182 variant and risk of hepatocellular carcinoma in a southern Chinese population
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PRIMARY RESEARCH
Open Access
A miR-182 variant and risk of hepatocellular carcinoma in a southern Chinese population Moqin Qiu1,2, Yingchun Liu1,3, Qiuling Lin1,2, Zihan Zhou1,2, Yanji Jiang1,2, Rongrui Huo1, Xiumei Liang1, Xiangyuan Yu4,5, Ji Cao1, Xianguo Zhou1,3* and Hongping Yu1,2,3*
Abstract MicroRNAs (miRNAs) play important roles in the regulation of gene expression at the posttranscriptional level and are involved in human carcinogenesis. The aim of the current study was to investigate the associations between miR-182 single nucleotide polymorphisms and HCC risk in a southern Chinese population. In this case-control study of 863 HCC patients and 908 cancer-free controls, we performed genotyping of miR-182 rs4541843 and assessed its association with HCC risk. We found that individuals carrying the AG/AA genotypes of miR-182 rs4541843 were significantly associated with an increased risk of HCC compared with those carrying the GG genotype (adjusted odds ratio (OR) = 1.71, 95% confidence interval (CI) = 1.07–2.76, P = 0.026). In the stratified analysis, this increased risk was more pronounced in the subgroups of older individuals (adjusted OR = 1.98, 95% CI = 1.04–3.76, P = 0.037), males (adjusted OR = 1.81, 95% CI = 1.09–2.99, P = 0.021), and never drinkers (adjusted OR = 1.84, 95% CI = 1.03–3.30, P = 0.041). Our results suggested that miR-182 polymorphism rs4541843 may contribute to the susceptibility to HCC. Our findings require validation in further studies with larger sample sizes. Keywords: Hepatocellular carcinoma, miR-182, Polymorphism, Risk, Association
Introduction The incidence of liver cancer in China is markedly higher than that in other geographical areas around the world [1]. In 2018, approximately 841,000 people worldwide were diagnosed with liver cancer, and approximately half of these diagnoses were in China [2]. The major histological subtype of liver cancer is hepatocellular carcinoma (HCC), accounting for approximately 75–80% of all cases [3]. Several key factors may contribute to HCC, such as hepatitis B/C virus (HBV/HCV) infection, cigarette smoking, and heavy drinking, but only a small fraction of exposed individuals eventually develop HCC in their lifetimes [4]. Recently, several genome-wide association studies have identified susceptible loci harboring common single nucleotide polymorphisms * Correspondence: [email protected]; [email protected] 1 Guangxi Medical University Cancer Hospital, Nanning 530021, China Full list of author information is available at the end of the article
(SNPs) that are relevant to the risk of HCC, suggesting that genetic factors may be responsible for susceptibility to HCC [5–8]. MicroRNAs (miRNAs) are a class of small non-coding RNAs that can regulate gene expression by pairing with the 3′ untranslated region (3′ UTR) of mRNAs [9]. To date, more than 1800 precursor miRNAs have been found in the human genome, and aberrant expression of miRNAs has been related to the etiology, diagnosis, and prognosis of many human cancers including HCC [10–12]. MiR-18
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