FTO gene polymorphisms and obesity risk in Chinese population: a meta-analysis
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META-ANALYSIS
FTO gene polymorphisms and obesity risk in Chinese population: a meta‑analysis Ning‑Ning Zhao1 · Guan‑Ping Dong1 · Wei Wu1 · Jin‑Ling Wang1 · Rahim Ullah1 · Jun‑Fen Fu1 Received: 3 December 2018 / Accepted: 28 March 2019 © Children’s Hospital, Zhejiang University School of Medicine 2019
Abstract Background There is tremendous increase in obesity worldwide. Many factors including diet, life style, genetic, and epigenetic changes contribute to obesity. The fat mass and obesity-associated (FTO) gene polymorphisms are strongly associated with obesity. It has been reported that FTO single-nucleotide polymorphisms (SNPs) are associated with obesity in European populations; however, it was controversial in Chinese population. The present meta-analysis study was designed to investigate the association between FTO polymorphisms and obesity risk in Chinese population. Methods The investigators searched studies using the following databases: PubMed, web of science, and Cochrane Central Register of Controlled Trials. A random-effects model was used to calculate the pooled odds ratios (ORs). The heterogeneity among the studies was measured by I2 value. Subgroup analysis was used to find out the potential factors influencing the heterogeneity. Results A total of 18 articles including 26 studies were included in the present meta-analysis. Overall, the FTO SNPs were significantly associated with obesity in Chinese population (OR 1.30; 95% CI 1.19–1.42; P
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