A Molecular and Cellular View of Protein Kinase CK2

It is now generally recognized that protein kinase signaling is involved in virtually every aspect of cell function, including growth and proliferation. The field of protein phosphorylation, including the enzymes involved in this post-translational modifi

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A Molecular. and Cellular View of

Protein Kinase CK2 Edited by

KHALIL AHMED

E.CHAMBAZ

Cellular and Molecular Biochemistry Research Laboratory (151) V.A. Medical Centre One Veterans Drive Minneapolis, MN 55417

Laboratoire de Biochemie des Regulations Cellulaires Endocrines INSERM U244 DBMS, CEA Grenoble, 17 rue des Martyrs F-38054 Grenoble Cedex 9, France

O.G.ISSINGER Biokemisk Institut Odense Universitet Campusvej 55, DK-5230 Odense M, Denmark

Reprinted from Molecular and Cellular Biochemistry, Volume 191 (1999)

Springer-Science+Business Media, B.V.

Library of Congress Cataloging-in-Publication Data

A molecular and cellular view of protein kinase CK2 / edited by Khalil Ahmed: E. Chambaz, 0.0. Issinger, co-editors p. cm. -- (Developments in molecular and cellular biochemistry) ISBN 978-1-4613-4648-7 ISBN 978-1-4419-8624-5 (eBook) DOI 10.1007/978-1-4419-8624-5 1. Protein kinase CK2--Congresses. 1. Ahmed, Khalil, 1934II. Chambaz E. M. III. Issinger, o. O. IV Series QP606.P76M65 1998 572'.792--dc21 98-8321 CIP

Printed on acid-free paper

Ali rights reserved © 1999 Springer Science+Business Media Dordrecht Originally published by Kluwer Academic Publishers in 1999 Softcover reprint ofthe hardcover Ist edition 1999 No part ofthe material protected by this copyright notice may be reproduced Of utilized in any form or by any means, electronic or mechanical, inc1uding photocopying, recording or by any information storage and retrieval system, without written permission [rom the copyright owner

Molecular and Cellular Biochemistry:

An International Journal for Chemical Biology in Health and Disease CONTENTS VOLUME 191, Nos. 1 & 2, January (II) 1999 A MOLECULAR AND CELLULAR VIEW OF PROTEIN KINASE CK2 Drs. Khalil Ahmed, E. Gambaz and O.G. Issinger

Preface G. Dobrowolska, FJ. Lozeman, D. Li and E.G. Krebs: CK2, a protein kinase of the next millennium S. Sarno, P. Vaglio, L. Cesaro, O. Marin and L.A Pinna: A multifunctional network of basic residues confers unique properties to protein kinase CK2 A Krehan and W. Pyerin: Intermolecular contact sites in protein kinase CK2 M.J. Benitez, G. Mier, E Brione, EJ. Moreno and J.S. Jimenez: Binding a polylysine to protein kinase CK2, measured by Surface Plasmon Resonance E Meggio, O. Marin, S. Sarno and L.A Pinna: Functional analysis ofCK2~-derived synthetic fragments D. Leroy, O. Filhol, N. Quintaine, D. Sarrouilhe, P. Loue-Mackenbach, E.M. Chambaz and C. Cochet: Dissecting subdomains involved in multiple functions of the CK2~ subunit M. Kusk, R. Ahmed, B. Thomsen, C. Bendixen, O.-G. Issinger and B. Boldyreff: Interactions of protein kinase CK2~ subunit within the holoenzyme and with other proteins U. Wirkner and W. Pyerin: CK2a loci in the human genome: Structure and transcriptional activity X. Xu, E. Landesman-Bollag, P.L. Channavajhala and D.C. Seldin: Murine protein kinase CK2: Gene and oncogene I. Korn, S. Gutkind, N. Srinivasan, T.L. Blundell, C.C.AlIende and lE.AlIende: Interactions of protein kinase CK2 subunits D. Leroy, G.C. Alghisi, E. Roberts, O. Filhol-Cochet