A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (M
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A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior BMC Medicine 2013, 11:64
doi:10.1186/1741-7015-11-64
Gerwyn Morris ([email protected]) George Anderson ([email protected]) Piotr Galecki ([email protected]) Michael Berk ([email protected]) Michael Maes ([email protected])
ISSN Article type
1741-7015 Review
Submission date
11 October 2012
Acceptance date
25 January 2013
Publication date
8 March 2013
Article URL
http://www.biomedcentral.com/1741-7015/11/64
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© 2013 Morris et al. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
A narrative review on the similarities and dissimilarities between myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and sickness behavior Gerwyn Morris1, George Anderson2, Piotr Galecki3, Michael Berk4-8 and Michael Maes4,9,* 1
Tir Na Nog, Bryn Road Seaside 87, Llanelli, SA152LW, UK
2
CRC Clinical Research Centre/Communications, Laurel Street 57, Glasgow, G11
7QT,UK 3
Department of Adult Psychiatry, Medical University of Lodz, Aleksandrowska 159,
Lodz, 91229, Poland 4
Barwon Health, School of Medicine, Deakin University, PO Box 291, Geelong,
3220, Australia 5
Orygen Youth Health Research Centre, Poplar Road 35, Parkville, 3052, Australia
6
Centre of Youth Mental Health, University of Melbourne, Poplar Road 35, Parkville,
3052, Australia 7
The Florey Institute for Neuroscience and Mental Health, University of Melbourne,
Kenneth Myer Building, Royal Parade 30, Parkville, 3052, Australia 8
Department of Psychiatry, University of Melbourne, Level 1 North, Main Block,
Royal Melbourne Hospital, Parkville, 3052, Australia 9
Department of Psychiatry, Chulalongkorn University, Rama 4 Road 1873,
Pathumwan, Bangkok, 10330, Thailand
*Corresponding author
Email addresses: GM: [email protected] GA: [email protected] PG: [email protected] MB: [email protected] MM: [email protected]
Abstract It is of importance whether myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a variant of sickness behavior. The latter is induced by acute infections/injury being principally mediated through proinflammatory cytokines. Sickness is a beneficial behavioral response that serves to enhance recovery, conserves energy and plays a role in the resolution of inflammation. There are behavioral/symp
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