Correction to: A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/
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Journal of Translational Medicine Open Access
CORRECTION
Correction to: A systematic review of mitochondrial abnormalities in myalgic encephalomyelitis/chronic fatigue syndrome/ systemic exertion intolerance disease Sean Holden1,2,3, Rebekah Maksoud1,3,4*, Natalie Eaton‑Fitch1,3,4, Hélène Cabanas1,3, Donald Staines1,3 and Sonya Marshall‑Gradisnik1,3
Correction to: J Transl Med (2020) 18:290 https://doi.org/10.1186/s12967-020-02452-3
Following publication of the original article [1], the authors identified errors in the Results section, in the Discussion section and in Tables 2 and 4.
Results section In the first paragraph of the ‘Participant and study characteristics’ sub-section, the third sentence requires corrections. The updated sentence is given below and the changes have been highlighted in bold typeface: Seven of the studies reported race, wherein the largest proportion of participants were Caucasian [6, 8, 12–14, 17, 22]. In the second paragraph of the ‘Participant and study characteristics’ sub-section, the first sentence requires corrections. The updated sentence is given below and the changes have been highlighted in bold typeface: Different sample types were sourced across the studies; five studies used peripheral blood mononuclear cells (PBMCs) [8, 18, 19, 23, 22], three studies used plasma [11, 13, 21], two studies used Natural Killer (NK) cells [14, The original article can be found online at https://doi.org/10.1186/s1296 7-020-02452-3. *Correspondence: [email protected] 1 National Centre for Neuroimmunology and Emerging Diseases (NCNED), Menzies Health Institute Queensland, Griffith University, Gold Coast, Australia Full list of author information is available at the end of the article
15], two studies used lymphoblasts [22, 23], two studies used mtDNA [6, 20], two studies used whole blood [5, 9], one study used cerebrospinal fluid [17], one study used neutrophils [7], one study used urine [5] and one study used percutaneous needle muscle biopsies [16]. The second paragraph of the ‘Literature reporting changes in mitochondrial respiratory function’ subsection, requires corrections. The updated paragraph is given below and the changes have been highlighted in bold typeface: Another study [22] examining lymphoblasts also showed lower mitochondrial membrane potential in ME/ CFS/SEID patients compared to HC participants. There was also lowered activation of ATP synthesis by complex V and hyperactivated target of rapamycin (TOR) complex 1 stress signaling. In Missailidis et al’s study [22] there was greater proton leak, greater complex 1 oxygen consumption rate (OCR), greater maximum OCR (OCR is an indicator of cellular metabolism and fitness) and greater spare respiratory capacity (excess respiratory electron transport chain capacity not being used in basal respiration) [12, 22, 28]. Additionally, in Missailidis et al’s study there was also greater nonmitochondrial OCR (oxygen consuming process) activity, greater number of enzymes of β-oxidation and greater tricarboxylic acid cycle (TCA
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