A New Zn(II) Complex: Fluorescent Detection of Fe 3+ Ions in Water and Prevention Effect on DVT By Regulating Platelets
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ORIGINAL ARTICLE
A New Zn(II) Complex: Fluorescent Detection of Fe3+ Ions in Water and Prevention Effect on DVT By Regulating Platelets Numbers and Activity of Clotting Factor Yue-Ying Pei 1 & Jie Gao 1 & Xin Liu 1 & Hong-Yuan Xue 1 Received: 12 June 2020 / Accepted: 27 July 2020 # Springer Science+Business Media, LLC, part of Springer Nature 2020
Abstract [Zn(dima)(H2O)0.5]·H2O (1), a three-dimensional metal organic framework (MOF) with high porosity was formed by selfassembly of 4,6-di(1 h-imidazol-1-yl)isophthalic acid (H2dima) and Zn2+ ion. Owning to its excellent luminescence and excellent water stability, complex 1 can be used as a super sensitive sensor to detect Fe3+ ions via the behaviors of fluorescence quenching. At the same time, the mechanism for the fluorescence quenching is also further discussed. Furthermore, the prevention effect of the compound on the deep vein thrombosis of the lower extremities (DVT) after lower venous CHIVA surgery was evaluated in vivo. Firstly, the DVT animal models was constructed and the number of platelets was measured with flow cytometry and content of clotting factor IX and anticoagulant factor III was also detected with Lowry method after compound treatment. The molecular docking simulation results indicate that the Zn(II) complex has activity to protein docking pocket with different sizes. Keywords Zn-MOF . Imidazole-carboxyl ligand . Porous framework . Fe3+ sensor . DVT . Molecular docking
Introduction Deep vein thrombosis (DVT) of lower extremities is an abnormal thrombosis of lower extremities in deep veins, resulting in strong venous obstruction, causing blood reflux disorders [1]. Lower venous CHIVA surgery has a long course of disease, which increases the number of platelets, the content of clotting factors and decreases the activity of anticoagulant factors [2]. In addition, the long-term bed rest of the patients causes the decrease of muscle contraction, which leads to a slowing of the blood flow velocity in the vein, an increase in blood viscosity, resulting in abnormal blood vessel condensation and thrombosis, and the formation of deep vein thrombosis of the lower extremity, which may cause pulmonary embolism, seriously affect the quality of life of patients, and even die in respiratory failure [3, 4]. The Fe3+ is widely used in industry and has a significant function in different processes of biochemistry at cell level [5]. Nevertheless, excessive Fe3+ will do harm to proteins and * Hong-Yuan Xue [email protected] 1
Department of Ultrasonography, Hebei General Hospital, Shijiazhuang, Hebei, China
nucleic acids, due to Fe3+ can catalyze Fenton reaction to produce active oxygen [6]. Thus, it is of important sense for environment and health of human beings to develop robust, reliable and efficient Fe 3+ detection approaches [7–9]. Luminescent metal organic frameworks (LMOFs) have attracted more and more attention because of their significant sensitivity, dual compatibility, simplicity of operation and high selectivity in solution and solid media [10–
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