A fluorescent coordination polymer for TNP detection and protection effect on cough after infection by up-regulates the
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ORIGINAL PAPER
A fluorescent coordination polymer for TNP detection and protection effect on cough after infection by up‑regulates the activity of neuroendopeptide enzyme in respiratory tract mucosa Yu Xu1 · Yi Guo2 · Jie Zhang3 Received: 9 July 2020 / Accepted: 18 September 2020 © The Polymer Society, Taipei 2020
Abstract Through utilizing the mixed-ligand method, a novel coordination polymer based on Zn(II) ions as nodes was synthesized under hydrothermal condition via applying 1,4-cyclohexanedicarboxylic acid (1,4-H2chdc) and 2-(4-fluoro-phenyl)1H-imidazo[4,5-f][1,10]phenanthroline (L), a π-electron rich ligand, as co-ligand, and its chemical formula is [Zn(1,4-chdc) (L)(H2O)]n (1). Because of its strong ambient temperature fluorescent emission and outstanding water stability, the complex 1 could be utilized as the sensitive sensor for the 2, 4, 6-trinitrophenol (TNP) via fluorescence quenching, and the constant of quenching can reach 2.794 × 105 M−1. The following experiment was further conducted to detect the treatment activity of the synthetic compound against post-infectious cough. The release of inflammatory cytokines and endopeptidase from respiratory tract mucosa was determined through enzyme linked immunosorbent assay (ELISA). Next, the fluorescent probe of DCFH-DA was utilized to detect the accumulation of ROS in the respiratory mucosal epithelial cells. Keywords Coordination polymer · Fluorescent sensor · TNP detection · Post-infectious cough
Introduction Cough is the most common symptom of cold, and 60-90% of cold patients are accompanied by cough symptoms. After the symptoms of the acute phase of most cold patients disappear, the cough symptoms still persist, which is clinically called post-cold cough [1]. Viruses, Mycoplasma pneumoniae, and Chlamydia pneumoniae can all cause such coughs, so they are also called post-infectious coughs. The post-infectious coughs can cause damage to the mucous membranes of the respiratory tract, which is manifested by the large amount of inflammatory factors secretion by airway epithelial cells and the decreased level of the neuropeptidase [2, 3]. In addition to this, the epithelial cells showed excessive inflammatory * Jie Zhang [email protected] 1
Geriatrics Department, Hunan Provincial People’s Hospital, Changsha, Hunan, China
2
Changsha Health Vocational Clinical College, Changsha, Hunan, China
3
Department of Internal Medicine, Yuelu Second People’s Hospital, Changsha, Hunan, China
response, which was displayed by the excessive accumulation of ROS in the epithelial cells of airway. At present, how to determine the harmful organic compounds quickly has become a significant challenge for human health, homeland security and the environmental protection [4–6]. The harmful nitroaromatic explosives (NAEs) are the significant raw materials for the industrial explosives, particularly for the TNP, when they were released to environment, they will cause water and soil pollution and latent explosion hazards. Hence, it is a challenging research topic to
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