A possible correlation between antioxidant and antidiabetic potentials of oxovanadium(IV) complexes
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Med Chem Res (2013) 22:2929–2937 DOI 10.1007/s00044-012-0287-4
ORIGINAL RESEARCH
A possible correlation between antioxidant and antidiabetic potentials of oxovanadium(IV) complexes A. Sheela • N. C. Sarada • R. Vijayaraghavan
Received: 30 March 2012 / Accepted: 20 October 2012 / Published online: 4 November 2012 Springer Science+Business Media New York 2012
Abstract Diabetes mellitus is one of the metabolic disorders resulting from excess production of reactive oxygen species (ROS) over the normal level and also due to dysfunction in the antioxidant defense mechanism, possibly both occurring simultaneously. Excess ROS are normally scavenged by antioxidants. Transition metal complexes exhibit such antioxidant property by scavenging the excess free radicals (one type of ROS) in such disorders. In this study, we report on synthesis, characterization, and in vitro study on antioxidant property of a few new ester-based vanadium(IV) complexes, namely, bis(1,1-dimethylethylpropanedioato)oxovanadium(IV)—[VO(DTBM)2]; bis(methyl-3-oxopentanoato) oxovanadium(IV)—[VO(MPA)2]; bis(ethyl-3-oxopentanoato) oxovanadium(IV)—[VO(EPA)2]; bis(2-methyl-1,3-dimethylpropanedioato)oxovanadium(IV)—[VO(DMMM)2] and bis (2-bromo-1,3-diethylpropanedioato)oxovanadium(IV)—[VO (BDEM)2], and also furan-based vanadium complexes. Antidiabetic potential of selected complexes has been estimated. An attempt has also been made to correlate antioxidant and antidiabetic potentials of selected complexes. Our study reveals that compounds exhibiting higher glucose lowering effect seem to possess good antioxidant potential as well. Keywords Ester-based Oxovanadium Antioxidant Glucose lowering
A. Sheela R. Vijayaraghavan (&) Materials Chemistry Division, Centre for Excellence in Nanomaterials, School of Advanced Sciences, VIT University, Vellore 632 014, Tamil Nadu, India e-mail: [email protected] N. C. Sarada Environmental & Analytical Chemistry Division, School of Advanced Sciences, VIT University, Vellore 632 014, Tamil Nadu, India
Introduction Oxidative stress results from a serious imbalance between reactive oxygen species (ROS) production and antioxidant defenses and can arise from an increased generation and/or reduced elimination of reactive species by the antioxidant defense system. The biologically relevant reactive species include reactive oxygen or nitrogen species (ROS and RNS) both in the form of free radicals as well as non-free radicals. The free radical forms are superoxide (O•2 ), hydroxyl (•OH), nitric oxide (•NO), and nitrogen dioxide (NO•2 ). The non-free radical forms include hydrogen peroxide (H2O2), peroxynitrite (OONO-) (Halliwell and Gutteridge, 2007; Halliwell, 2011). Under normal physiological conditions, a delicate balance exists between the rate of generation and consumption of free radicals. This is facilitated by the integrated antioxidant defense mechanism, both exogenous and endogenous origin, playing a pivotal role in various physiological functions (Jacob, 1995). In this regard, antioxidant is defined a
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