A Simple and Efficient Method for Quantitative Synthesis of Cu (II) Complexes in Presence of SiO 2 : Structure Elucidati
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ORIGINAL PAPER
A Simple and Efficient Method for Quantitative Synthesis of Cu (II) Complexes in Presence of SiO2: Structure Elucidation, DFT, Eukaryotic DNA, Antimicrobial and Potentiometric Studies Zehba A. Al-Ahmed 1 & Naema Yarkandy 2 Received: 3 October 2019 / Accepted: 18 March 2020 # Springer Nature B.V. 2020
Abstract An effective methodology for the quantitative preparation of copper (II) complexes from benzaldehyde-[N-(3-Hydroxy-2Naphthoyl)] Hydrazone (H2L) in existence of SiO2 as a catalyst which reduced reaction time and produced high yield was discussed. The formed complexes were elucidated by applying spectral, analytical and conformational methods. The octahedral configuration was proposed for Cu (II) complexes based on magnetic moments, electronic spectral and electron spin resonance (ESR). The DFT theory used to predict the optimized atomic-skeletons for all produced complexes. Also, biological activity measurements were performed to study the important of produced compounds. The association constants of ligand at various temperatures in 50% (v/v) DMSO/H2O, 0.05 M were calculated by applying potentiometric titration. Also, the stability constants of copper (II) compounds were calculated in DMSO/H2O as a mixed solvent at various temperatures. Keywords Schiff bases . SiO2 . DFT . DNA . Potentiometric titration
1 Introduction The Schiff bases complexes have a great deal of medical interest in their biological efficacy as anticancer agents. The magnitude of this practical research was situated in the aspiration to an application that benefits humanity in addressing the cancer. Therefore, new Schiff bases will be used from derivatives that known to have broad biological activity, especially towards cancer, some viruses, bacteria and parasites [1–4]. Also, metals complexes are fundamental cellular components chosen to function in numerous
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s12633-020-00463-9) contains supplementary material, which is available to authorized users. * Zehba A. Al-Ahmed [email protected] 1
Department of Chemistry, College of art and sciences, King Khalid University, Abba, Saudi Arabia
2
Department of Chemistry, Faculty of Applied Science, Umm Al-Qura University, Makkah Almukaramah, Mecca, Saudi Arabia
essential biochemical processes for living organisms. Generally, metals have unique characteristics that involve reactivity towards organic substrates, variable coordination modes, and redox activity. For these reasons, the design of special coordination complexes, whichever as drug or prodrug, was considered the main target to get a powerful tools in cancer diagnosis [5–7]. There are many chosen biologically active metals were considered interest in the creation a unique anti-cancer drug. Transition metals like copper (II) were concerned in several biological processes such as electron transfer, catalysis, structural roles, and also, were often related to the active sites of enzymes and proteins [8, 9]. However, deregulation
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