Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals
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RESEARCH ARTICLE
Comparative study of serum zinc concentration in recurrent herpes labialis patients and healthy individuals Zahra Ranjbar1, Maryam Zahed1* , Mohammad Ali Ranjbar2 and Zahra Shirmardan3
Abstract Background: Recurrent herpes labialis (RHL) is a common recurrent infective vesiculoulcerative disease. Topical and systemic administration of Zinc compounds has been indicated to have preventive and therapeutic effects. The purpose of this study was to evaluate the serum level of zinc in the patients with RHL and healthy individuals and also to investigate the correlation of this level with various parameters of the patient and disease course. Methods: This cross-sectional study was performed on 43 patients with a history of recurrent herpers labialis and 42 subjects without any previous experience of the lesion. Blood samples were taken, and serum zinc level was measured using colorimetry (spectrophotometry) method. Chi-Square test was used to compare the qualitative relationships, and for comparing the quantitative relationships, independent T-test was used. To observe the relationshipof quantitative factors including serum zinc level, the number of relapses, and recovery rates, correlation test was taken. Results: The results show that, serum zinc level has no significant difference between healthy subjects and the patients (p > 0.05). Also, zinc level was not related to age and sex factors and frequency of relapse (p > 0.05). However surprisingly, there was a significant relationship between zinc level and recovery period in the RHL patients. The lower the serum zinc level, the higher the duration of recovery (p = 0.009). Conclusion: The results of this study indicate that, zinc deficiency can be considered as a risk factor for increasing the duration of herpes labialis lesions. Therefore, the evaluation of serum zinc level in the subjects with RHL and subsequent administration of zinc are recommended in these kind of patients. Keywords: Herpes labialis, Zinc, Serum Background Herpes simplex virus type 1 (HSV-1), as a member of the herpes virus family, is the etiologic factor of a variety of diseases such as primary gingivostomatitis, recurrent herpes labialis, and recurrent intraoral herpetic lesions. Accordingly, it generally affects the upper parts of the human body, and the primary infection appears *Correspondence: [email protected]; [email protected] 1 Oral and Dental Disease Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran Full list of author information is available at the end of the article
after fluid or skin contact with contaminated individuals [1, 2]. In most of the cases, the virus tends to remain in the sensory ganglions or skin epithelium after the initial infection [3]. Factors such as sunlight, shock, stress, fever, and hormonal changes can trigger the reactivation of the virus causing a secondary or recurrent lesion like herpes labialis [1, 2]. Herpes labialis primarily appe
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