A targeted drug delivery system based on carbon nanotubes loaded with lobaplatin toward liver cancer cells
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ARTICLE A targeted drug delivery system based on carbon nanotubes loaded with lobaplatin toward liver cancer cells Shiping Yua) Interventional Treatment Department, Second Hospital of Shanxi Medical University, Taiyuan 030001, China; and Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China
Qiang Li Interventional Treatment Department, Second Hospital of Shanxi Medical University, Taiyuan 030001, China
Junli Wang Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China; and Research Center on Advanced Materials Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China
Jinglei Du Interventional Treatment Department, Second Hospital of Shanxi Medical University, Taiyuan 030001, China
Yuduan Gao Ophthalmology Department, Shanxi Dayi Hospital, Taiyuan 030032, China
Li Zhang Urology Department, Shanxi Dayi Hospital, Taiyuan 030032, China
Lin Chen and Yongzhen Yangb) Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China; and Research Center on Advanced Materials Science and Technology, Taiyuan University of Technology, Taiyuan 030024, China
Xuguang Liu Key Laboratory of Interface Science and Engineering in Advanced Materials of Ministry of Education, Taiyuan University of Technology, Taiyuan 030024, China (Received 2 January 2018; accepted 4 June 2018)
To eliminate the toxic effect of chemotherapy drug of lobaplatin (LBP) on body tissue in liver cancer therapy, this work prepared a nanodrug carrier based on polyethylene glycol-modified carbon nanotubes (PEG–CNTs) and then constructed a targeted drug delivery system (LBP–PEG–CNTs) by loading LBP on PEG–CNTs. Fluorescein isothiocyanate (FITC) was used to label PEG–CNTs to observe the cellular uptake of PEG–CNTs. In addition, the inhibitions of LBP–PEG–CNTs on HepG2 cells were investigated. The results show that the FITC-labeled PEG–CNTs have good cell penetrability; meanwhile, LBP–PEG–CNTs have good stability, pH-controlled release property, and high inhibition rate on HepG2 cells. To be specific, 80% of LBP is released under physiological conditions of liver cancer cells at pH 5.0, and LBP–PEG–CNTs show a high inhibition rate of 77.86% on HepG2 cells, demonstrating that they have targeted, pH-controlled release and inhibition properties on HepG2 cells.
I. INTRODUCTION
Liver cancer is one of the most common cancers in the world, and the majority of patients with liver cancer will die within one year as a result of the cancer. There is substantial interest in developing therapeutic options for treatment of liver cancer.1 At present, chemotherapy plays an important role in dealing with liver tumor, which is mainly based on Address all correspondence to these authors. a) e-mail: [email protected] b) e-mail: [email protected] DOI: 10.1557/jmr.2018.197
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