A Toxicologist's Guide to Clinical Pathology in Animals Hematology,
This guide provides an easy-to-use desk reference for diagnostic information on commonly used hematology, clinical chemistry, and urinalysis parameters. Additional reference materials are provided as an aid in evaluating clinical pathology data. For many
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A Toxicologist’s Guide to Clinical Pathology in Animals Hematology, Clinical Chemistry, Urinalysis
A Toxicologist’s Guide to Clinical Pathology in Animals
John E. Whalan
A Toxicologist’s Guide to Clinical Pathology in Animals ▪ Hematology ▪ Clinical Chemistry ▪ Urinalysis
John E. Whalan Office of Research and Development United States Environmental Protection Agency Washington DC, USA
Much of this Work was first published in Chinese language in 2014 by Shanghai Popular Science Press under the title: ⭆樴≐䈑ᷜ⸲㡨樴㊯⋿ (A Guide to Clinical Pathology in Animals). ISBN 978-3-319-15852-5 ISBN 978-3-319-15853-2 DOI 10.1007/978-3-319-15853-2
(eBook)
Library of Congress Control Number: 2015936603 Springer Cham Heidelberg New York Dordrecht London © Springer International Publishing Switzerland 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Springer International Publishing AG Switzerland is part of Springer Science+Business Media (www. springer.com)
Preface
For many toxicologists, the evaluation of hematology, clinical chemistry, and urinalysis data can be the most daunting part of animal toxicity studies. When dozens of parameters are measured for each animal at regular intervals throughout a study, there may be hundreds or even thousands of data points to consider. What does it mean when a parameter value increases for an individual or for a group? What does it mean when it decreases? When a parameter change is statistically significant does that mean it is biologically significant? What other parameters can be used to strengthen a diagnosis? What is causing these changes? The answers to these questions can be found in veterinary clinical pathology textbooks, of course, and every toxicologist should own at least one or two; but searching for diagnostic information in textbooks can be difficult and time consuming. Many years ago, I began keeping a notebook of key information and diagnoses for the clinical pathology parameters used in toxicolog
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