Aberrant resting-state functional connectivity of salience network in first-episode schizophrenia
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ORIGINAL RESEARCH
Aberrant resting-state functional connectivity of salience network in first-episode schizophrenia Huan Huang 1,2 & Zeng Botao 3 & Yuchao Jiang 4 & Yingying Tang 2 & Tianhong Zhang 2 & Xiaochen Tang 2 & Lihua Xu 2 & Junjie Wang 2 & Jin Li 2 & Zhenying Qian 2 & Xu Liu 2 & Huiling Wang 1 & Cheng Luo 4 & Chunbo Li 2,5,6 & Jian Xu 7 & Donald Goff 8 & Jijun Wang 2,5,6
# Springer Science+Business Media, LLC, part of Springer Nature 2019
Abstract The disruption of salience network (SN) has been consistently found in patients with schizophrenia and thought to give rise to specific symptoms. However, the functional dysconnectivity pattern of SN remains unclear in first-episode schizophrenia (FES). Sixty-five patients with FES and sixty-six health controls (HC) were enrolled in this study and underwent resting-state functional magnetic resonance imaging (rs-fMRI). The eleven regions of interest (ROIs) within SN were derived from the peaks of the group independent component analysis (gICA). Seed-based whole-brain functional connectivity (FC) analyses were performed with all SN ROIs as the seeds. Both hyper- and hypo-connectivity of SN were found in the FES. Specifically, the increased FC mainly existed between the SN and cortico-cerebellar sub-circuit and prefrontal cortex, while the reduced FC mainly existed within cortico-striatal-thalamic-cortical (CSTC) sub-circuit. Our findings suggest that FES is associated with pronounced dysregulation of SN, characterized prominently by hyperconnectivity of SN-prefrontal cortex and cerebellum, as well as hypoconnectivity of CSTC sub-circuit of the SN. Keywords First-episode schizophrenia . Resting-state functional magnetic resonance imaging . Salience network . Functional connectivity
Introduction The underlying etiology of schizophrenia remains largely unclear. It is generally thought to involve alterations in neural circuits that support sensory, cognitive, and emotional
processes (Stephan et al. 2009; Pettersson-Yeo et al. 2011), which could better explain the range of various impairments seen in this illness. Resting-state functional magnetic resonance imaging (rs-fMRI) is an excellent non-invasive tool to explore brain in vivo; it is easy to implement and has been
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s11682-019-00040-8) contains supplementary material, which is available to authorized users. * Jian Xu [email protected] * Jijun Wang [email protected] 1
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Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiaotong University School of Medicine, Shanghai 200030, China Department of Psychiatry, Qingdao Mental Health Center, Qingdao, China
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Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China
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CAS Center for Excellence in Brain Science and Intelligence
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