Abnormal dynamic resting-state brain network organization in auditory verbal hallucination
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ORIGINAL ARTICLE
Abnormal dynamic resting‑state brain network organization in auditory verbal hallucination Haiyang Geng1,2 · Pengfei Xu3,4,5 · Iris E. Sommer2 · Yue‑Jia Luo1,4,6 · André Aleman1,2 · Branislava Ćurčić‑Blake2 Received: 10 February 2020 / Accepted: 23 July 2020 © The Author(s) 2020
Abstract Auditory-verbal hallucinations (AVH) are a key symptom of schizophrenia. Recent neuroimaging studies examining dynamic functional connectivity suggest that disrupted dynamic interactions between brain networks characterize complex symptoms in mental illness including schizophrenia. Studying dynamic connectivity may be especially relevant for hallucinations, given their fluctuating phenomenology. Indeed, it remains unknown whether AVH in schizophrenia are directly related to altered dynamic connectivity within and between key brain networks involved in auditory perception and language, emotion processing, and top-down control. In this study, we used dynamic connectivity approaches including sliding window and k-means to examine dynamic interactions among brain networks in schizophrenia patients with and without a recent history of AVH. Dynamic brain network analysis revealed that patients with AVH spent less time in a ‘network-antagonistic’ brain state where the default mode network (DMN) and the language network were anti-correlated, and had lower probability to switch into this brain state. Moreover, patients with AVH showed a lower connectivity within the language network and the auditory network, and lower connectivity was observed between the executive control and the language networks in certain dynamic states. Our study provides the first neuroimaging evidence of altered dynamic brain networks for understanding neural mechanisms of AVH in schizophrenia. The findings may inform and further strengthen cognitive models of AVH that aid the development of new coping strategies for patients. Keywords Auditory-verbal hallucinations · Dynamic connectivity · Network-antagonistic state · Default model network · Language network
Introduction
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00429-020-02119-1) contains supplementary material, which is available to authorized users.
Auditory-verbal hallucinations (AVH) are perceptual experiences in the absence of external auditory-verbal stimuli, which are sufficiently compelling to be considered as true perceptions. AVH are a characteristic symptom in schizophrenia, and approximate 70% of patients report AVH at 3
* Pengfei Xu [email protected]
Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China
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Yue‑Jia Luo [email protected]
Center for Emotion and Brain, Shenzhen Institute of Neuroscience, Shenzhen, China
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Great Bay Neuroscience and Technology Research Institute (Hong Kong), Kwun Tong, Hong Kong, China
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Sichuan Center of Applied Psychology, Chengdu Medical College, Chengdu, China
* Haiyang Geng [email protected]
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