Abnormal Local Activity and Functional Dysconnectivity in Patients with Schizophrenia Having Auditory Verbal Hallucinati
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40(5):979-984,2020
979
Abnormal Local Activity and Functional Dysconnectivity in Patients with Schizophrenia Having Auditory Verbal Hallucinations* Cheng CHEN1, Gao-hua WANG1, 2, Shi-hao WU1, Ji-lin ZOU1, Yuan ZHOU3, 4, Hui-ling WANG1, 5# 1 Department of Psychiatry, Renmin Hospital of Wuhan University, Wuhan 430060, China 2 Hubei Institute of Neurology and Psychiatry Research, Wuhan 430060, China 3 CAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China 4 Department of Psychology, University of Chinese Academy of Sciences, Beijing 100049, China 5 Hubei Provincial Key Laboratory of Developmentally Originated Disease, Wuhan 430071, China Huazhong University of Science and Technology 2020
Summary: Auditory verbal hallucination (AVH) is emphasized as a pathological hallmark of schizophrenia. Neuroimaging studies provide evidence linking AVH to overlapping functional abnormalities in distributed networks. However, no clear conclusion has still been reached. This study aimed to further explore the brain activity of patients with schizophrenia having AVH from both local activity (LA) and functional connectivity (FC) insights, while excluding confounding factors from other positive symptoms. A total of 42 patients with AVH (AVH patients group, APG), 26 without AVH (non-AVH patients group, NPG), and 82 normal controls (NC) underwent restingstate functional magnetic resonance imaging (fMRI). LA measures, including regional homogeneity (ReHo) and fractional amplitude of low-frequency fluctuations (fALFF), and FC measures were evaluated to understand the neuroimaging mechanism of AVH. APG showed increased ReHo and fALFF in the bilateral putamen (Put) compared with NPG and NC. FC analysis (using bilateral putamen as seeds) revealed that all patients showed abnormal FC of multiple resting-state network regions, including the anterior and post cingulate cortex, middle frontal gyrus, inferior parietal gyrus, and left angular gyrus. Interestingly, APG showed significantly decreased FC of insula extending to the superior temporal gyrus and inferior frontal gyrus compared with NPG and NC. The present findings suggested a significant correlation of abnormal LA and dysfunctional putamen–auditory cortical connectivity with the neuropathological mechanism of AVH, providing evidence for the functional disconnection hypothesis of schizophrenia. Key words: auditory verbal hallucination; functional connectivity; local activity; resting-state functional magnetic resonance imaging; schizophrenia
Auditory verbal hallucination (AVH), as a core pathological feature of schizophrenia, usually presents in 60%–90% of cases and may result in emotional and behavioral dysfunctions[1–3]. To date, multiple models have been proposed for the mechanisms of AVH. Based on resting-state functional magnetic resonance imaging (rs-fMRI) studies, evidence related to AVH showed an association of the occurrence of AVH with multiple special distributed networks, including the default mode network (DMN)[4, 5] and reduced frontotempo
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