Abnormalities in carbohydrate and lipid metabolisms in high-fructose dietfed insulin-resistant rats: amelioration by Cat
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ORIGINAL PAPER
Abnormalities in carbohydrate and lipid metabolisms in high-fructose dietfed insulin-resistant rats: amelioration by Catharanthus roseus treatments Karuna Rasineni & Ramesh Bellamkonda & Sreenivasa Reddy Singareddy & Saralakumari Desireddy
Received: 3 June 2012 / Accepted: 2 January 2013 # University of Navarra 2013
Abstract High intake of dietary fructose has been shown to exert a number of adverse metabolic effects in humans and experimental animals. The present study was proposed to elucidate the effect of Catharanthus roseus (C. roseus) leaf powder treatment on alterations in carbohydrate and lipid metabolisms in rats fed with high-fructose diet. Male Wistar rats of body weight around 180 g were divided into four groups, two of these groups (groups C and C+CR) were fed with standard pellet diet and the other two groups (groups F and F+CR) were fed with highfructose (66 %) diet. C. roseus leaf powder suspension in water (100 mg/kg body weight/day) was administered orally to group C+CR and group F+CR. At the end of a 60-day experimental period, biochemical parameters related to carbohydrate and lipid metabolisms were assayed. C. roseus treatment completely prevented the fructose-induced increased body weight, hyperglycemia, and hypertriglyceridemia. Hyperinsulinemia and insulin resistance observed in group F was significantly decreased with C. roseus treatment in group F+CR. The alterations observed in the activities K. Rasineni : S. R. Singareddy : S. Desireddy (*) Department of Biochemistry, Sri Krishnadevaraya University, Anantapur 515 003, Andhra Pradesh, India e-mail: [email protected] R. Bellamkonda Department of Biochemistry, Sri Venkateswara University, Tirupati 517502, Andhra Pradesh, India
of enzymes of carbohydrate and lipid metabolisms and contents of hepatic tissue lipids in group F rats were significantly restored to near normal values by C. roseus treatment in group F+CR. In conclusion, our study demonstrates that C. roseus treatment is effective in preventing fructose-induced insulin resistance and hypertriglyceridemia while attenuating the fructoseinduced alterations in carbohydrate and lipid metabolisms. This study suggests that the plant can be used as an adjuvant for the prevention and/or management of insulin resistance and disorders related to it. Keywords High-fructose diet . Fructose-induced insulin resistance . Catharanthus roseus . Hypertriglyceridemia
Introduction Insulin resistance and type 2 diabetes mellitus have reached epidemic proportions worldwide with the global adoption of the Western diet along with increased consumption of fructose, stemming from the wide and increasing use of high-fructose corn syrup sweeteners [5, 36]. Consumption of sucrose and more recently of high-fructose corn syrup (HFCS) has increased dramatically through processed foods such as beverages, jams, jellies, baked goods, and dairy products. HFCS is inexpensive and sweeter than sucrose which increases its palatability and hence is rapidly replacing sucrose in processed foods; this ha
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