Effect of diosmin on lipid peoxidation and organ damage against subacute deltamethrin exposure in rats
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RESEARCH ARTICLE
Effect of diosmin on lipid peoxidation and organ damage against subacute deltamethrin exposure in rats Muhammet Yasin Tekeli 1 & Gökhan Eraslan 1
&
Latife Çakır Bayram 2 & Zeynep Soyer Sarıca 3
Received: 25 March 2020 / Accepted: 15 October 2020 # Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract The aim of this study was to investigate the protective efficacy of diosmin against subacute deltamethrin exposure. For this purpose, 40 male Wistar albino rats were used. The animals were assigned to the following 4 groups: control group (received corn oil vehicle alone), diosmin-treated group (50 mg/kg bw/day orally), deltamethrin-exposed group (5 mg/kg bw/day, orally) and coadministered group (5 mg/kg bw/day deltamethrin and 50 mg/kg bw/day diosmin, orally) for 28 days. Some lipid peroxidation/ antioxidant status/biochemical markers were evaluated in blood/tissue (liver, kidney, brain, heart and testis) samples and the histopathological architecture was assessed. Compared with the control group, no alteration was detected in the parameters and histological findings of the diosmin-treated group. Deltamethrin toxicity was associated with significantly increased plasma, cardiac, hepatic, renal, cerebral and testicular levels of MDA and NO, and significantly decreased GSH levels (p < 0.05). Antioxidant enzyme status (SOD, CAT and GSH-Px activities) displayed either decrease or increase (p < 0.05). Significant increase was detected in AST and ALT activities and urea and creatinine levels (p < 0.05). The values of the group coadministered with deltamethrin and diosmin were similar to the values of the control group. Diosmin ameliorated deltamethrin-induced lymphocytic and histiocytic infiltration and subendocardial oedema in the heart. Combined administration also minimized hepatic, renal, testicular and cerebral histopathological findings. The alterations detected in various toxicological parameters correlated well with the histopathological changes observed in various organs. In conclusion, it is suggested that diosmin could provide protection against deltamethrin-induced toxicity and organ damage in rats. Keywords Deltamethrin . Diosmin . Lipid peroxidation . Antioxidant status . Histopathological findings . Rat
Introduction Deltamethrin is a broad spectrum type II synthetic pyrethroid insecticide, which is widely used against pests (ants, mites, insects) in agriculture. It is also used topically for the control of urban green areas, resident and garden pests, as well as vector-borne diseases transmitted to farm animals by ticks, Responsible Editor: Mohamed M. Abdel-Daim * Gökhan Eraslan [email protected] 1
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey
2
Department of Pathology, Faculty of Veterinary Medicine, Erciyes University, Kayseri, Turkey
3
Hakan Çetinsaya Experimental and Clinical Research Center, Erciyes University, Kayseri, Turkey
mites, fleas and flies. Due to its rapid metabolism, and low toxicit
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