Acenocoumarol
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Elevated INR: case report A 33-year-old woman exhibited elevated INR during treatment with acenocoumarol for internal carotid artery (ICA) dissection. The woman presented with anisocoria and headache. About one month prior to the current presentation, she had suffered a minor head trauma. At the current presentation, investigations showed right intracranial ICA dissection. She thus started receiving acenocoumarol [dosage and route not stated]. One week later, she was hospitalised with immeasurably high INR and recurring right sided headache. A new, spontaneous left sided ICA dissection was diagnosed. She was subsequently found to have 46 XY karyotype with primary gonadal dysgenesis and MTHFR C677T homozygous mutation, which were thought to be risk factors for the ICA dissection. The woman’s therapy with acenocoumarol was however continued [outcome not stated]. Takacs TT, et al. Case report of bilateral intracranial internal carotid artery dissection in a patient with female phenotype, 46XY karyotype and homozygous MTHFR C677T mutation. European Journal of Neurology 27 (Suppl. 1): 1049 (plus poster) abstr. EPO3051, May 2020. Available from: URL: https://onlinelibrary.wiley.com/doi/ 803498444 epdf/10.1111/ene.14308 [abstract]
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Reactions 29 Aug 2020 No. 1819
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