Acute effect of ambient fine particulate matter on heart rate variability: an updated systematic review and meta-analysi
- PDF / 2,059,327 Bytes
- 15 Pages / 595.276 x 790.866 pts Page_size
- 16 Downloads / 168 Views
(2020) 25:77
Environmental Health and Preventive Medicine
REVIEW ARTICLE
Open Access
Acute effect of ambient fine particulate matter on heart rate variability: an updated systematic review and meta-analysis of panel studies Zhiping Niu1,2†, Feifei Liu1,2†, Baojing Li3, Na Li1,2, Hongmei Yu4, Yongbo Wang1, Hong Tang1,2, Xiaolu Chen1,2, Yuanan Lu5, Zilu Cheng6, Suyang Liu1,2, Gongbo Chen7, Yuxiao Zhang1,2* and Hao Xiang1,2*
Abstract Background: Decreased heart rate variability (HRV) is a predictor of autonomic system dysfunction, and is considered as a potential mechanism of increased risk of cardiovascular disease (CVD) induced by exposure to particulate matter less than 2.5 μm in diameter (PM2.5). Previous studies have suggested that exposure to PM2.5 may lead to decreased HRV levels, but the results remain inconsistent. Methods: An updated systematic review and meta-analysis of panel studies till November 1, 2019 was conducted to evaluate the acute effect of exposure to ambient PM2.5 on HRV. We searched electronic databases (PubMed, Web of Science, and Embase) to identify panel studies reporting the associations between exposure to PM2.5 and the four indicators of HRV (standard deviation of all normal-to-normal intervals (SDNN), root mean square of successive differences in adjacent normal-to-normal intervals (rMSSD), high frequency power (HF), and low frequency power (LF)). Random-effects model was used to calculate the pooled effect estimates. Results: A total of 33 panel studies were included in our meta-analysis, with 16 studies conducted in North America, 12 studies in Asia, and 5 studies in Europe. The pooled results showed a 10 μg/m3 increase in PM2.5 exposure which was significantly associated with a − 0.92% change in SDNN (95% confidence intervals (95%CI) − 1.26%, − 0.59%), − 1.47% change in rMSSD (95%CI − 2.17%, − 0.77%), − 2.17% change in HF (95%CI − 3.24%, − 1.10%), and − 1.52% change in LF (95%CI − 2.50%, − 0.54%), respectively. Overall, subgroup analysis suggested that short-term exposure to PM2.5 was associated with lower HRV levels in Asians, healthy population, and those aged ≥ 40 years. Conclusion: Short-term exposure to PM2.5 was associated with decreased HRV levels. Future studies are warranted to clarity the exact mechanism of exposure to PM2.5 on the cardiovascular system through disturbance of autonomic nervous function. Keywords: Fine particulate matter, Heart rate variability, Panel study, Meta-analysis
* Correspondence: [email protected]; [email protected] † Zhiping Niu and Feifei Liu contributed equally to this work. 1 Department of Global Health, School of Health Sciences, Wuhan University, 115# Donghu Road, Wuhan, China Full list of author information is available at the end of the article © The Author(s). 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the sour
Data Loading...
