Acute Promyelocytic Leukemia Molecular Genetics, Mouse Models and Ta
Over the past 10 years, work on acute promyelocytic leukemia (APL) has become the paradigm of translational research that began with the discovery of a recurrent chromosomal translocation, followed by the identification of the genes and proteins involved,
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Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · C. Svanborg, Lund P.K. Vogt, La Jolla/California · H. Wagner, Munich
P.P. Pandolfi and P.K. Vogt (Eds.)
Acute Promyelocytic Leukemia Molecular Genetics, Mouse Models and Targeted Therapy
With 16 Figures and 12 Tables
123
Pier Paolo Pandolfi, MD, Ph.D. Sloan-Kettering-Institute Memorial Sloan-Kettering Cancer Center 1275 York Avenue New York, New York 10021 USA e-mail: p-pandolfi@ski.mskcc.org Peter K. Vogt, Ph.D. The Scripps Research Institute 10550 North Torreye Pines Road La Jolla, CA 92037 USA e-mail: [email protected] Cover Illustration: APL: a journey of discovery from gene identification to cure. The understanding of the molecular genetics underlying the disease and faithful modeling of the disease in the mouse has been instrumental in developing and optimizing effective treatment modalities in preclinical trials. As a result, this form of leukemia is now considered curable.
Library of Congress Catalog Number 72-152360 ISSN 0070-217X ISBN-10 3-540-34592-2 Springer Berlin Heidelberg New York ISBN-13 978-3-540-34592-3 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2007 The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such information by consulting the relevant literature. Editor: Simon Rallison, Heidelberg Desk editor: Anne Clauss, Heidelberg Production editor: Nadja Kroke, Leipzig Cover design: WMX Design, Heidelberg Typesetting: LE-TEX Jelonek, Schmidt & Vöckler GbR, Leipzig Printed on acid-free paper SPIN 11735670 27/3150/YL – 5 4 3 2 1 0
List of Contents
APL as a Paradigm in Biomedical Research: A Journey Toward the Cure . . . . . . . P. P. Pandolfi
1
Mouse Models of Acute Promyelocytic Leukemia . . . . . . . . . . . . . . . . . . . . . . . S. C. Kogan
3
The PLZF Gene of t(11;17)-Associated APL . . . . . . . . . . . . . . . . . . . . . . .
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