Genetics of the Mouse
This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of th
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s of the Mouse
Genetics of the Mouse
Jean Louis Guénet · Fernando Benavides Jean-Jacques Panthier · Xavier Montagutelli
Genetics of the Mouse
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Jean Louis Guénet Institut Pasteur (Emeritus) Paris France
Jean-Jacques Panthier Mouse Functional Genetics Unit Institut Pasteur Paris France
Fernando Benavides Division of Basic Science Research Department of Molecular Carcinogenesis The University of Texas MD Anderson Cancer Center Smithville, TX USA
and Ecole Nationale Vétérinaire d’Alfort Maisons-Alfort France Xavier Montagutelli Mouse Functional Genetics Unit Institut Pasteur Paris France
ISBN 978-3-662-44286-9 ISBN 978-3-662-44287-6 (eBook) DOI 10.1007/978-3-662-44287-6 Library of Congress Control Number: 2014945779 Springer Heidelberg New York Dordrecht London © Springer-Verlag Berlin Heidelberg 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
This book is dedicated to the memory of Professor François Jacob (June 1920–April 2013)
Foreword
The science of experimental biology rests on the analysis of causative factors, followed by synthesis. Commonly, the analytic step involves determining the consequences of a known perturbation. Classical experimental biology rested on perturbations of the environment, or on surgical operations such as transplanta
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