The BALB/c Mouse Genetics and Immunology
The mouse was first used in immunological research by Paul Ehrlich in 1891 in an extraordinary series of experiments on the maternal transfer of antitoxic immunity. A short 22 years later in 1913 Halsey Bagg acquired a stock of albino mice from a commerci
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Editors A. Clarke, ParkvilleNictoria . R W. Compans, Birmingham/Alabama . M. Cooper, Birmingham/Alabama H. Eisen, Paris . W. Goebel, Wiirzburg . H. Koprowski, Philadelphia . F. Melchers, Basel . M. Oldstone, La Jolla/California· R Rott, GieBen . P.K Vogt, Los Angeles H. Wagner, U1m . I. Wilson, La Jolla/California
The BALB/c Mouse Genetics and Immunology Edited by M. Potter
With 85 Figures
Springer-Verlag Berlin Heidelberg NewYork Tokyo
MICHAEL POTTER, M.D.
Chief, Laboratory of Genetics National Institutes of Health National Cancer Institute Bethesda, MD 20205, USA
ISBN -13: 978-3-642-70742-1 DOT: 10.1007/978-3-642-70740-7
e- ISBN -13:978-3-642-707-7
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically those of translation, reprinting, re-use of illustrations, broadcasting, reproduction by photocopying machine or similar means, and storage in data banks. Under § 54 of the Germin Copyright Law where copies are made for other than private use, a fee is payable to "Verwertungsgesellschaft Wort", Munich. © by Springer-Verlag Berlin Heidelberg 1985 Softcover reprint of the hardcover 1st edition 1985
Library of Congress Catalog Card Number 15-12910 The use of registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product Liability: The publishers can give no guarantee for information about drug dosage and application thereof contained in this book. In every individual case the respective user must check its accuracy by consulting other pharmaceutical literature.
2123/3130-543210
Preface
The mouse was first used in immunological research by Paul Ehrlich in 1891 in an extraordinary series of experiments on the maternal transfer of antitoxic immunity. A short 22 years later in 1913 Halsey Bagg acquired a stock of albino mice from a commercial dealer and used them in a series of experiments on learning. Because he was interested in the genetics of intelligence, Halsey Bagg began breeding a pedigreed line of these mice that were subsequently named for him - Bagg Albino. Though Halsey Bagg is not credited with initiating the inbred strains of mice, his stock curiously has played an indisputably important role. Bagg Albinos were progenitors of the present day BALB/c family of sublines - the subject of this book. They were also used as one of the parents in the development of inbred strains A, CBA and C3H, three other very famous strains. Today the BALB/c mouse is among the five most widely used inbred strains in biomedical research and a particular favorite in immunology and infectious disease research. The hallmark of the BALB/c response to so many kinds of infections is susceptibility and sometimes an exaggerated susceptibility, but this paradoxically is not associated with immunodeficiency as BALB/c is an excellent responder to immunization. These characteristics h
