Adjunctive treatment with probiotics partially alleviates symptoms and reduces inflammation in patients with irritable b
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ORIGINAL CONTRIBUTION
Adjunctive treatment with probiotics partially alleviates symptoms and reduces inflammation in patients with irritable bowel syndrome Haiyan Xu1,2 · Chen Ma1,2 · Feiyan Zhao1,2 · Ping Chen3 · Yahua Liu1,2 · Zhihong Sun1,2 · Lihong Cui4 · Lai‑Yu Kwok1,2 · Heping Zhang1,2 Received: 17 August 2020 / Accepted: 4 November 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Purpose Irritable bowel syndrome (IBS) is a functional bowel disorder. This study aimed to assess the effect of a probiotic product (containing Lactobacillus casei Zhang, Lactobacillus plantarum P-8, and Bifdobacterium animalis subsp. lactis V9) as an adjunct to a routine regimen in IBS management. Methods Forty-five patients with IBS were randomized into the probiotic (n = 24) and control (n = 21) groups, receiving the routine regimen with or without probiotics for 28 days, respectively. Serum and fecal samples were collected and analyzed. Results The IBS-symptom severity score (P
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