Adjuvant versus early salvage radiotherapy: outcome of patients with prostate cancer treated with postoperative radiothe

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Adjuvant versus early salvage radiotherapy: outcome of patients with prostate cancer treated with postoperative radiotherapy after radical prostatectomy Marco M. E. Vogel1,2, Kerstin A. Kessel1,2,3, Kilian Schiller1, Michal Devecka1, Jürgen E. Gschwend4, Wilko Weichert3,5, Jan J. Wilkens1 and Stephanie E. Combs1,2,3*

Abstract Background: Adjuvant (ART) and salvage radiotherapy (SRT) are two common concepts to enhance biochemical relapse free survival (BCRFS) in patients with prostate cancer (PC). We analyzed differences in outcome between ART and SRT in patients with steep decline of PSA-levels after surgery to compare outcome. Methods: We evaluated 253 patients treated with postoperative RT with a median age of 66 years (range 42–85 years) treated between 2004 and 2014. Patients with additive radiotherapy due to PSA persistence and patients in the SRT group, who did not achieve a postoperative PSA level