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ORIGINAL ARTICLE

Early C‑reactive protein kinetics predict survival of patients with advanced urothelial cancer treated with pembrolizumab Toshiki Kijima1 · Hina Yamamoto1 · Kazutaka Saito1   · Shota Kusuhara2 · Soichiro Yoshida1 · Minato Yokoyama1 · Yoh Matsuoka1 · Noboru Numao3 · Yasuyuki Sakai4 · Nobuaki Matsubara2 · Takeshi Yuasa3 · Hitoshi Masuda5 · Junji Yonese3 · Yukio Kageyama4 · Yasuhisa Fujii1 Received: 14 March 2020 / Accepted: 20 August 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020

Abstract Objective  To assess the prognostic and predictive ability of early C-reactive protein (CRP) kinetics, dynamic changes in CRP levels, in patients with advanced urothelial cancer treated with pembrolizumab. Patients and methods  We retrospectively evaluated 97 patients with advanced urothelial cancer treated with pembrolizumab in second-line or later settings. Patients were divided into three early CRP kinetics groups: non-elevated (baseline CRP 

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