Advanced Methods in Structural Biology
This book provides practical information on a whole set of protein experiments for advanced structural biology, such as X-ray crystallography, NMR, electron microscopy, advanced mass spectroscopy, and surface plasmon resonance, as well as a wide variety o
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Toshiya Senda Katsumi Maenaka Editors
Advanced Methods in Structural Biology
SPRINGER PROTOCOLS HANDBOOKS
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Advanced Methods in Structural Biology Editors
Toshiya Senda Institute of Materials Structure Science, High Energy Accelerator Research Organization (KEK), Tsukuba, Japan
Katsumi Maenaka Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
Editors Toshiya Senda Institute of Materials Structure Science High Energy Accelerator Research Organization (KEK) Tsukuba, Japan
Katsumi Maenaka Faculty of Pharmaceutical Sciences Hokkaido University Sapporo, Japan
ISSN 1949-2448 ISSN 1949-2456 (electronic) Springer Protocols Handbooks ISBN 978-4-431-56028-9 ISBN 978-4-431-56030-2 (eBook) DOI 10.1007/978-4-431-56030-2 Library of Congress Control Number: 2016942541 © Springer Japan 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Japan KK
Preface Structural genomics studies have advanced the development of standard protocols for structural biology, leading to several automated experimental methods. As a result, it has become much easier to determine the tertiary structure of proteins. Indeed, the number of atomic coordinates of protein molecules in the Protein Data Bank (PDB) has been rapidly increasing in the last decade, with the current total exceeding 110,000 coordinates. Nonetheless, many difficult problems remain to be overcome in structural biology. For example, the structure determination of large protein complexes and membrane proteins is still difficult and often hard to accomplish using the simple standard protocols that are currently available. In many cases, researchers require more complex protocols that are specific to the protein complexes they are targeting. However, there are few textbooks focusing on these technical challenges. The pur
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