Advances in Cell Seeding of Tissue Engineered Vascular Grafts
From the advent of tissue engineered vascular grafts (TEVG), cells have often been included in the fabrication process in order to provide biological signals to the host and ultimately lead to improved outcomes. How the cells are integrated into the TEVG
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Contents 1 Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Cell Seeding Techniques for Vascular Grafts . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.1 Static . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.2 Quasi-Static Techniques to Enhance Cell Engraftment . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2.3 Dynamic Techniques . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Cell and Scaffold Sources . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3.1 Cell Sourcing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3.2 Scaffold Materials . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Recent Advances in Cell-based TEVGs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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J. S. Weinbaum Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA e-mail: [email protected] D. G. Haskett Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA e-mail: [email protected] T. F. Mandelkern Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA e-mail: [email protected] D. A. Vorp (*) Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA Department of Cardiothoracic Surgery, University of Pittsburgh, Pittsburgh, PA, USA Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, USA McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA e-mail: [email protected] © Springer Nature Switzerland AG 2020 B. H. Walpoth et al. (eds.), Tissue-Engineered Vascular Grafts, Reference Series in Biomedical Engineering, https://doi.org/10.1007/978-3-030-05336-9_10
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5 Future Directions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 309 6 Conclusions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 311 References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
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