Advances in Bioinformatics and Computational Biology Third Brazi

This book constitutes the refereed proceedings of the Third Brazilian Symposium on Bioinformatics, BSB 2008, held in Sao Paulo, Brazil, in August 2008 - co-located with IWGD 2008, the International Workshop on Genomic Databases. The 14 revised full papers

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Edited by S. Istrail, P. Pevzner, and M. Waterman Editorial Board: A. Apostolico S. Brunak M. Gelfand T. Lengauer S. Miyano G. Myers M.-F. Sagot D. Sankoff R. Shamir T. Speed M. Vingron W. Wong

Subseries of Lecture Notes in Computer Science

Ana L.C. Bazzan Mark Craven Natália F. Martins (Eds.)

Advances in Bioinformatics and Computational Biology Third Brazilian Symposium on Bioinformatics, BSB 2008 Santo André, Brazil, August 28-30, 2008 Proceedings

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Series Editors Sorin Istrail, Brown University, Providence, RI, USA Pavel Pevzner, University of California, San Diego, CA, USA Michael Waterman, University of Southern California, Los Angeles, CA, USA Volume Editors Ana L.C. Bazzan Instituto de Informática, UFRGS Porto Alegre, RS, Brazil E-mail: [email protected] Mark Craven University of Wisconsin Madison, Wisconsin, USA E-mail: [email protected] Natália F. Martins EMBRAPA, Recursos Genéticos e Biotecnologia Brasília, DF, Brazil E-mail: [email protected]

Library of Congress Control Number: 2008932956

CR Subject Classification (1998): H.2.8, F.2.1, I.2, G.2.2, J.2, J.3, E.1 LNCS Sublibrary: SL 8 – Bioinformatics ISSN ISBN-10 ISBN-13

0302-9743 3-540-85556-4 Springer Berlin Heidelberg New York 978-3-540-85556-9 Springer Berlin Heidelberg New York

This work is subject to copyright. All rights are reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broadcasting, reproduction on microfilms or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September 9, 1965, in its current version, and permission for use must always be obtained from Springer. Violations are liable to prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springer.com © Springer-Verlag Berlin Heidelberg 2008 Printed in Germany Typesetting: Camera-ready by author, data conversion by Scientific Publishing Services, Chennai, India Printed on acid-free paper SPIN: 12453382 06/3180 543210

Preface

The Brazilian Symposium on Bioinformatics (BSB) 2008 was held at Santo Andr´e (S˜ ao Paulo), Brazil, August 28–30, 2008. BSB 2008 was the third symposium in the BSB series, although BSB was preceded by the Brazilian Workshop on Bioinformatics (WOB). This previous event had three consecutive editions in 2002 (Gramado, Rio Grande do Sul), 2003 (Maca´e, Rio de Janeiro), and 2004 (Bras´ılia, Distrito Federal). The change from workshop to symposium reflects the increasing quality and interest behind this meeting. For BSB 2008, we had 41 submissions: 32 full papers and 9 extended abstracts, submitted to two tracks: the main track on Computational Biology and Bioinformatics, and the track Applications of Agent Technologies and Multiagent Systems to Computational Biology. The current proceedings contain 14 full papers and 5 extended abstracts that were accepted. These papers and abstracts w