Tumor Immunology Methods and Protocols

This volume explores the still undiscovered secrets of tumor immunology and cancer immunology by discussing the methods and techniques that world-renowned experts in the field use in their laboratories.  This book provides a better understanding of t

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Attilio Bondanza Monica Casucci Editors

Tumor Immunology Methods and Protocols

METHODS

IN

MOLECULAR BIOLOGY

Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK

For further volumes: http://www.springer.com/series/7651

Tumor Immunology Methods and Protocols

Edited by

Attilio Bondanza Vita-Salute San Raffaele University, Milano, Italy; Innovative Immunotherapies Unit, IRCCS San Raffaele Hospital Scientific Institute, Milano, Italy

Monica Casucci Innovative Immunotherapies Unit, IRCCS San Raffaele Hospital Scientific Institute, Milano, Italy

Editors Attilio Bondanza Vita-Salute San Raffaele University Milano, Italy Innovative Immunotherapies Unit IRCCS San Raffaele Hospital Scientific Institute Milano, Italy

Monica Casucci Innovative Immunotherapies Unit IRCCS San Raffaele Hospital Scientific Institute Milano, Italy

ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-3336-5 ISBN 978-1-4939-3338-9 (eBook) DOI 10.1007/978-1-4939-3338-9 Library of Congress Control Number: 2015958743 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)

Preface Tumor immunology is the branch of immunology that studies the interactions between the immune system and tumor cells. Closely related to tumor immunology, cancer immunotherapy is a growing field of therapeutic intervention aimed at exploiting immune cells and molecules to fight human tumors. Given the extremely high human and economical burden that cancer brings to our industrial societies, it is understandable how, from its very beginnings at the end of the nineteenth century, tumor immunology was shaped around the promise of effective cancer immunotherapy.