Agaricus bisporus supplementation reduces high-fat diet-induced body weight gain and fatty liver development
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ORIGINAL ARTICLE
Agaricus bisporus supplementation reduces high-fat diet-induced body weight gain and fatty liver development María Iñiguez 1 & Patricia Pérez-Matute 1 & María Jesús Villanueva-Millán 1 & Emma Recio-Fernández 1 & Irene Roncero-Ramos 2 & Margarita Pérez-Clavijo 2 & José-Antonio Oteo 1,3 Received: 27 December 2017 / Accepted: 12 September 2018 # University of Navarra 2018
Abstract Obesity is a global epidemic characterized not only by excessive fat deposition but also by important complications such as nonalcoholic liver steatosis. Beneficial antiobesogenic effects have been described for some mushrooms. The current study aimed to demonstrate the protective effect of Agaricus bisporus (AB) supplementation against the metabolic alterations induced by high-fat-diet (HFD) feeding. Eight-week-old C57BL/6J mice were fed for 10 weeks with one of the following diets: (1) control diet (n = 7), (2) HFD (n = 7), (3) HFD supplemented with 5% AB (n = 9), and (4) HFD supplemented with 10% AB (n = 9). A pair-fed group was also included for the 10% AB group (n = 6). The impact of AB supplementation on food intake, body weight gain, and liver and fat pad weights was examined. Biochemical, histological, and molecular parameters were also analyzed. Dietary supplementation with 10% AB reduced the HFD-induced increase in body, epididymal, and mesenteric fat weights (p < 0.01, p < 0.05, and p < 0.05, respectively). Supplementation with AB also reduced liver damage in a dose-dependent manner (p < 0.01 and p < 0.001). This effect was confirmed by histological analysis that showed that liver steatosis was markedly reduced in mice fed with AB. The beneficial properties of 10% AB supplementation appear to be mediated through a decrease in food intake and via stimulation of mesenteric and hepatic free-fatty acid beta-oxidation, along with a decrease in epidydimal and hepatic expression of CD36. In conclusion, supplementation with AB prevents excessive body weight gain and liver steatosis induced by HFD consumption. Keywords Agricus bisporus . Liver steatosis . High-fat diet-induced obesity
Introduction An increase in sedentary lifestyles and diet modifications has provoked a progressive rise in the incidence of obesity [27]. Currently, more than 1.9 billion adults are considered overweight or obese, accounting for more than 13% of the adult population, and the problem is growing (http://www.who.int/ en/). In addition, rising obesity rates worldwide are leading to
* Patricia Pérez-Matute [email protected] 1
Infectious Diseases, Microbiota and Metabolism Unit, Infectious Diseases Department, Center for Biomedical Research of La Rioja (CIBIR), Piqueras 98, 3rd floor, 26006 Logroño, La Rioja, Spain
2
Mushroom Technological Research Center of La Rioja (CTICH), Autol, La Rioja, Spain
3
Infectious Diseases Department, Hospital San Pedro, Logroño, La Rioja, Spain
an increase of obesity-related complications such as cardiovascular disease, dyslipidemia, and insulin resistance, conditions that markedly affect quality of lif
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