Age-related change in episodic memory: role of functional and structural connectivity between the ventral posterior cing
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ORIGINAL ARTICLE
Age‑related change in episodic memory: role of functional and structural connectivity between the ventral posterior cingulate and the parietal cortex Manon Edde1,2,7 · Bixente Dilharreguy2 · Guillaume Theaud6 · Sandra Chanraud1,2,3 · Catherine Helmer4 · Jean‑François Dartigues3,4,5 · Hélène Amieva4 · Michèle Allard1,2,5 · Maxime Descoteaux6 · Gwénaëlle Catheline1,2,3 Received: 22 January 2019 / Accepted: 23 July 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract While the neural correlates of age-related episodic memory decline have been extensively studied, the precise involvement of the Posterior Cingulate Cortex (PCC) and posterior parietal cortex (the precuneus and the angular gyrus), remains unclear. The present study examined functional and structural neural correlates of age-related episodic memory change assessed over 12 years in 120 older adults (range 76–90 years). Episodic memory performance was measured using the Free and Cued Selective Reminding Test (FCSRT); functional connectivity metrics were computed from resting-state fMRI images and structural connectivity metrics were assessed through microstructural properties of reconstructed tract using a native space pipeline. We found that FCSRT change was significantly associated with the functional connectivity between the ventral PCC and three parietal regions, the ventral superior, the inferior part of the precuneus, and the rostro dorsal part of the angular gyrus. This association was independent of hippocampal volume. In addition, we found the that change in FCSRT scores was associated with fractional anisotropy of the tract connecting the ventral PCC and the ventral superior part of the precuneus. Change in episodic memory in aging was therefore related to a combination of high functional connectivity and low structural connectivity between the ventral PCC and the ventral superior part of the precuneus. Keywords Episodic memory change · Older adult · Functional connectivity · Structural connectivity · Parietal cortex · Posterior cingulate cortex
Introduction Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00429-020-02121-7) contains supplementary material, which is available to authorized users. * Manon Edde [email protected] 1
EPHE, PSL, 33000 Bordeaux, France
2
CNRS, INCIA, UMR 5287, 33000 Bordeaux, France
3
INCIA, UMR 5287, Université de Bordeaux, 33000 Bordeaux, France
4
Inserm, Bordeaux Population Health Research Center, UMR 1219, Université de Bordeaux, 33000 Bordeaux, France
5
CHU de Bordeaux, Bordeaux, France
6
Sherbrooke Connectivity Imaging Lab (SCIL), Université de Sherbrooke, Sherbrooke, QC, Canada
7
Bât. 2A ‑ 2ème Étage ‑ Case 22, 146 Rue Léo Saignat, 33076 Bordeaux cedex, France
Over the years, understanding why some older adults present significant cognitive decline while others maintain unimpaired cognitive ability has gained increasing attention (Nyberg 2016; Cabeza et al. 2018). Brain functional compensation to
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