Albumin in Medicine Pathological and Clinical Applications
This book presents a comprehensive overview of medical and pharmaceutical applications of human serum albumin (HSA), with updates on structural aspects of albumin from the perspectives of X-ray crystallography and NMR, endogenous and exogenous ligand bind
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bumin in Medicine Pathological and Clinical Applications
Albumin in Medicine
Masaki Otagiri • Victor Tuan Giam Chuang Editors
Albumin in Medicine Pathological and Clinical Applications
Editors Masaki Otagiri Faculty of Pharmaceutical Sciences Sojo University Kumamoto, Japan
Victor Tuan Giam Chuang School of Pharmacy, Faculty of Health Sciences Curtin University Perth, WA, Australia
ISBN 978-981-10-2115-2 ISBN 978-981-10-2116-9 DOI 10.1007/978-981-10-2116-9
(eBook)
Library of Congress Control Number: 2016953185 © Springer Science+Business Media Singapore 2016 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper This Springer imprint is published by Springer Nature The registered company is Springer Science+Business Media Singapore Pte Ltd.
Preface
Human serum albumin (HSA) is the most extensively researched plasma protein to date. Technological advancements in genetic engineering and molecular and structural biology have progressed in tandem with albumin research, especially in the area of applications, where rapid progress and development have resulted in massive favorable outputs for which albumin has clearly been proven to be a robust biomaterial. Owing to its relatively long in vivo half-life of approximately 19 days, albumin is an attractive recombinant genetic fusion partner for extending the half-life of peptides and small proteins. The genetic modification of albumin also allows it to be applied to a wide variety of in vivo purposes including the targeting of specific types of cells or organs for the delivery of albumin-bound drugs. A recent landmark finding in the metabolism of HSA is the discovery of its pH-dependent interaction with the intracellular neonatal Fc receptor. The Fc receptor–albumin interaction can be intervened in a therapeutically useful manner to manipulate the half-life of albuminbound drugs and albumin fusion proteins. The enormous ligand-binding properties of HSA can be applied in extracorporeal albumin dialysis, a pro
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