Nuclear Medicine Therapy Principles and Clinical Applications
Nuclear Medicine Therapy presents the state of the art in targeted radionuclide therapy, both in clinical practice and contemporary clinical investigation and trials. With contributions from an internationally-distinguished group of physicians and scienti
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Cumali Aktolun • Stanley J. Goldsmith Editors
Nuclear Medicine Therapy Principles and Clinical Applications
Editors Cumali Aktolun Tirocenter Nuclear Medicine Center Istanbul, Turkey
Stanley J. Goldsmith Division of Nuclear Medicine and Molecular Imaging New York-Presbyterian Hospital Weill College of Medicine of Cornell University NY, USA
ISBN 978-1-4614-4020-8 ISBN 978-1-4614-4021-5 (eBook) DOI 10.1007/978-1-4614-4021-5 Springer New York Heidelberg Dordrecht London Library of Congress Control Number: 2012942473 © Springer Science+Business Media New York 2013 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Duplication of this publication or parts thereof is permitted only under the provisions of the Copyright Law of the Publisher’s location, in its current version, and permission for use must always be obtained from Springer. Permissions for use may be obtained through RightsLink at the Copyright Clearance Center. Violations are liable to prosecution under the respective Copyright Law. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. While the advice and information in this book are believed to be true and accurate at the date of publication, neither the authors nor the editors nor the publisher can accept any legal responsibility for any errors or omissions that may be made. The publisher makes no warranty, express or implied, with respect to the material contained herein. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
‘To our patients and mentors who have taught us in the past and continue to teach us about life and medicine.’ Cumali Aktolun, MD, MSc Stanley J. Goldsmith, MD
Foreword
Targeting radioactive molecules to a disease process for imaging is well accepted and has disseminated rapidly. PET/CT with FDG has revolutionized cancer imaging and cancer management in the past two decades. The concept of nuclear medicine therapy (RIT) of cancers and other diseases has been and remains an attractive one. While radionuclide therapy is well accepted for benign and malignant thyroid diseases, its growth in application to other diseases has been slower. There has been great p
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