Altered immune phenotype and DNA methylation in panic disorder
- PDF / 906,162 Bytes
- 10 Pages / 595.276 x 790.866 pts Page_size
- 34 Downloads / 199 Views
Open Access
RESEARCH
Altered immune phenotype and DNA methylation in panic disorder Curtis L. Petersen1,2, Ji‑Qing Chen3, Lucas A. Salas4 and Brock C. Christensen4,5,6*
Abstract Background: Multiple studies have related psychiatric disorders and immune alterations. Panic disorder (PD) has been linked with changes in leukocytes distributions in several small studies using different methods for immune characterization. Additionally, alterations in the methylation of repetitive DNA elements, such as LINE-1, have been associated with mental disorders. Here, we use peripheral blood DNA methylation data from two studies and an updated DNA methylation deconvolution library to investigate the relation of leukocyte proportions and methylation status of repetitive elements in 133 patients with panic disorder compared with 118 controls. Methods and results: We used DNA methylation data to deconvolute leukocyte cell-type proportions and to infer LINE-1 element methylation comparing PD cases and controls. We also identified differentially methylated CpGs associated with PD using an epigenome-wide association study approach (EWAS), with models adjusting for sex, age, and cell-type proportions. Individuals with PD had a lower proportion of CD8T cells (OR: 0.86, 95% CI: 0.78–0.96, P-adj = 0.030) when adjusting for age, sex, and study compared with controls. Also, PD cases had significantly lower LINE-1 repetitive element methylation than controls (P
Data Loading...
