DNA Methylation: Basic Mechanisms
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Editors R.W. Compans, Atlanta/Georgia M.D. Cooper, Birmingham/Alabama T. Honjo, Kyoto · H. Koprowski, Philadelphia/Pennsylvania F. Melchers, Basel · M.B.A. Oldstone, La Jolla/California S. Olsnes, Oslo · M. Potter, Bethesda/Maryland P.K. Vogt, La Jolla/California · H. Wagner, Munich
W. Doerfler and P. Böhm (Eds.)
DNA Methylation: Basic Mechanisms With 24 Figures and 3 Tables
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Walter Doerfler, Prof. Dr. Petra Böhm Universität zu Köln Institut für Genetik Zülpicher Str. 47 50674 Köln Germany e-mail: walter.doerfl[email protected], [email protected]
Walter Doerfler, Prof. Dr. Universität Erlangen Institut für Klinische und Molekulare Virologie Schlossgarten 4 91054 Erlangen Germany e-mail: walter.doerfl[email protected]
Cover illustration: Methylation Profile of Integrated Adenovirus Type 12 DNA In the genome of the Ad12-transformed hamster cell line TR12, one copy of Ad12 DNA (green line) and a fragment of about 3.9kb from the right terminus (red line) of the Ad12 genome are chromosomally integrated (fluorescent in situ hybridization, upper left corner of illustration). The integrated viral sequence has remained practically identical with the sequence of the virion DNA. All 1634 CpG´s in this de novo methylated viral insert have been investigated for their methylation status by bisulfite sequencing. A small segment of these data is shown at the bottom of the graph. Open symbols indicate unmethylated CpG´s, closed symbols methylated 5-mCpG dinucleotides. This figure has been prepared by Norbert Hochstein, Institute for Clinical and Molecular Virology, Erlangen University and is based on data from a manuscript in preparation (N. Hochstein, I. Muiznieks, H. Brondke, W. Doerfler). Library of Congress Catalog Number 72-152360 ISSN 0070-217X ISBN-10 3-540-29114-8 Springer Berlin Heidelberg New York ISBN-13 978-3-540-29114-5 Springer Berlin Heidelberg New York This work is subject to copyright. All rights reserved, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilm or in any other way, and storage in data banks. Duplication of this publication or parts thereof is permitted only under the provisions of the German Copyright Law of September, 9, 1965, in its current version, and permission for use must always be obtained from Springer-Verlag. Violations are liable for prosecution under the German Copyright Law. Springer is a part of Springer Science+Business Media springeronline.com © Springer-Verlag Berlin Heidelberg 2006 Printed in Germany The use of general descriptive names, registered names, trademarks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. Product liability: The publisher cannot guarantee the accuracy of any information about dosage and application contained in this book. In every individual case the user must check such in
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