DNA Methylation Protocols
This third edition volume expands on the previous editions with a comprehensive update on the available technologies required to successfully perform DNA methylation analysis. The different technologies discussed in this book analyze the global DNA methyl
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Jörg Tost Editor
DNA Methylation Protocols Third Edition
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
DNA Methylation Protocols Third Edition Edited by
Jörg Tost Laboratory for Epigenetics and Environment Centre National de Recherche en Génomique Humaine, CEA—Institut de Biologie Francois Jacob Evry, France
Editor Jo¨rg Tost Laboratory for Epigenetics and Environment Centre National de Recherche en Ge´nomique Humaine CEA—Institut de Biologie Francois Jacob Evry, France
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-7479-5 ISBN 978-1-4939-7481-8 (eBook) https://doi.org/10.1007/978-1-4939-7481-8 Library of Congress Control Number: 2017960297 © Springer Science+Business Media, LLC 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Cover caption: Merged immunostaining of a mouse brain for 5-methylcytosine, single-stranded DNA and total DNA – Image taken from Chapter 4 of this volume: “Antibody Based Detection of Global Nuclear DNA Methylation in Cells, Tissue Sections and Mammalian Embryos” by Sari Pennings and Nathalie Beaujean et al. Printed on acid-free paper This Humana Press imprint is published by Springer Nature The registered company is Springer Science+Business Media, LLC The registered company address is: 233 Spring Street, New York, NY 10013, U.S.A.
Preface It is my great pleasure to introduce the third edition of DNA Methylation: Methods and Protocols to the scientific and medical community. DNA methylation at cytosines forms one of the multiple layers of epigenetic mechanisms controlling and modulating gene expression through chromatin structure. It closely interacts with histone modifications and chromatin remodeling complex
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