Alzheimer: 100 Years and Beyond

Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4th, 1906 in Tübingen. The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiative of the Alzheimer

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Editor Yves Christen, Fondation Ipsen, Paris (France)

Editorial Board Yves Agid, Hôpital Pitié Salpêtrière, Paris (France) Albert Aguayo, McGill University, Montreal (Canada) Brian H. Anderton, Institute of Psychiatry, London (GB) Raymond T. Bartus, Alkermes, Cambridge (USA) Anders Björklund, University of Lund (Sweden) Floyd Bloom, Scripps Clinic and Research Foundation, La Jolla (USA) François Boller, Inserm U 324, Paris (France) Carl Cotman, University of California, Irvine (USA) Peter Davies, Albert Einstein College of Medicine, New York (USA) Andre Delacourte, Inserm U 422, Lille (France) Steven Ferris, New York University Medical Center, New York (USA) Jean-François Foncin, Hôpital Pitié Salpêtrière, Paris (France) Françoise Forette, Hôpital Broca, Paris (France) Fred Gage, Salk Institute, La Jolla (USA) Dmitry Goldgaber, State University of New York Stone Brook (USA) John Hardy, National Institute of Health, Bethesda (USA) Jean-Jacques Hauw, Hôpital Pitié Salpêtrière, Paris (France) Claude Kordon, Inserm U 159, Paris (France) Kenneth S. Kosik, Harvard Medical School, Center for Neurological Diseases and Brigham and Women’s Hospital, Boston (USA) Jacques Mallet, Hôpital Pitié Salpêtrière, Paris (France) Colin L. Masters, University of Melbourne, Parkville (Australia) Stanley I. Rapoport, National Institute on Aging, Bethesda (USA) Barry Reisberg, New York University Medical Center, New York (USA) Allen Roses, Duke University Medical Center, Durham (USA) Dennis J. Selkoe, Harvard Medical School, Center of Neurological Diseases and Brigham and Women’s Hospital, Boston (USA) Michael L. Shelanski, Columbia University, New York (USA) Pierre-Marie Sinet, Hôpital Necker, Paris (France) Peter St. George-Hyslop, University of Toronto, Toronto (Canada) Robert Terry, University of California, La Jolla (USA) Edouard Zarifian, Centre Hospitalier Universitaire, Caen (France)

M. Jucker K. Beyreuther C. Haass R.M. Nitsch Y. Christen (Eds.)

Alzheimer: 100 Years and Beyond With 143 Figures

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Mathias Jucker Department of Cellular Neurology Hertie Institute for Clinical Brain Research University of Tübingen 72076 Tübingen Germany e-mail: [email protected]

Konrad Beyreuther Centre for Molecular Biology The University of Heidelberg Neuenheimer Feld 282 6900 Heidelberg Germany e-mail: [email protected]

Christian Haass Adolf-Butenandt-Institute Department of Biochemistry Laboratory for Alzheimer’s and Parkinson’s Disease Research Ludwig-Maximilians-University 80336 Munich Germany e-mail: [email protected]

Roger M. Nitsch Division of Psychiatry Research University of Zurich 8008 Zurich Switzerland e-mail: [email protected] Yves Christen Foundation IPSEN Pour la Recherche Thérapeutique 24, rue Erlanger 75781 Paris Cedex 16 France e-mail: [email protected]

Cover illustration by Ingram Pinn

ISSN 0945-6066 ISBN-10 3-540-37651-8 Springer Berlin Heidelberg New York ISBN-13 978-3-540-37651-4 Springer Berlin Heidelberg New York This work is subject to copyright. All rights are re