Celiac Disease Methods and Protocols
This volume provides detailed molecular analysis of the associated pathways and cell types involved in Celiac Disease, and embraces new technologies such as next generation sequencing. The book is divided into three parts: Part I gives a background overvi
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Anthony W. Ryan Editor
Celiac Disease Methods and Protocols
METHODS
IN
MOLECULAR BIOLOGY
Series Editor John M. Walker School of Life and Medical Sciences University of Hertfordshire Hatfield, Hertfordshire, AL10 9AB, UK
For further volumes: http://www.springer.com/series/7651
Celiac Disease Methods and Protocols
Edited by
Anthony W. Ryan Department of Clinical Medicine, Trinity College Dublin; Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James’s Hospital, Dublin, Ireland.
Editor Anthony W. Ryan Department of Clinical Medicine Trinity College Dublin Dublin, Ireland Institute of Molecular Medicine Trinity Centre for Health Sciences St James’s Hospital Dublin, Ireland
ISSN 1064-3745 ISSN 1940-6029 (electronic) Methods in Molecular Biology ISBN 978-1-4939-2838-5 ISBN 978-1-4939-2839-2 (eBook) DOI 10.1007/978-1-4939-2839-2 Library of Congress Control Number: 2015944312 Springer New York Heidelberg Dordrecht London © Springer Science+Business Media New York 2015 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. Printed on acid-free paper Humana Press is a brand of Springer Springer Science+Business Media LLC New York is part of Springer Science+Business Media (www.springer.com)
Preface Recent decades have seen considerable advances in our understanding of celiac disease. The condition, once thought to be limited to individuals of European ancestry, has been discovered at varying prevalence in North Africa, the Middle East, India, and China. The precipitating auto-antigen has been characterized. The genetic association of the HLA region was discovered early and refined in the years that followed. However, conclusive identification of non-HLA genetic risk proved elusive until the advent of genome-wide association studies, which have extended our understanding of the genetic component far beyond what could have been envisaged a short time ago. Current estimates suggest that more than 50% of the population variability associated with celiac dis
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