Amending the Efficiency of Antimicrobials against Multidrug-Resistant Pseudomonas aeruginosa by Low-Frequency Magnetic F
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ficiency of Antimicrobials against MultidrugResistant Pseudomonas aeruginosa by Low-Frequency Magnetic Fields Muna Salman Al-Delaimi1 and Haval Y. Yacoob Aldosky2
Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 170, No. 7, pp. 45-49, July, 2020 Original article submitted May 27, 2019 We studied the effect of 1- and 2-h exposure to low-frequency magnetic fields (0.3 and 0.42 mT) on the sensitivity of Pseudomonas aeruginosa to 18 antibiotics. P. aeruginosa samples were obtained from 20 patients with burns. Exposure to magnetic field reduced the resistance of P. aeruginosa and increased their susceptibility to antimicrobial drugs. This increase was positively correlated with field intensity and duration of exposure. After 2-h exposure to 0.42 mT, susceptibility of P. aeruginosa to antimicrobial drugs aztreonam, ceftazidime, colistin, imipenem, levofloxacin, and meropenem significantly increased. In addition, resensitization of P. aeruginosa to carbapenems, penicillin, quinolones, and aminoglycosides groups was observed. Key Words: multidrug-resistance; low frequency-magnetic field; Pseudomonas aeruginosa; antimicrobials susceptibility; burn injury Antibiotic resistance is a growing clinical problem and a major public health threat [7]. Infections caused by antibiotic-resistant bacteria are believed to result in higher mortality rates, longer durations of hospital stay, and higher health care costs compared to those that result from infections with their antibiotic-susceptible counterparts [6]. Pseudomonas aeruginosa is a major cause of nosocomial infections and is known for its resistance to many antibiotics [7]. Nosocomial infections caused by P. aeruginosa are often difficult to treat because of both the intrinsic resistance of this bacterium and its remarkable ability to acquire further resistance mechanisms to multiple groups of antimicrobial drugs, including β-lactams, aminoglycosides, and fluoroquinolones [12]. Complication caused by P. aeruginosa are often observed in patients with immunodeficiency related to AIDS, diabetes mellitus, or severe burns. However, infection of burn wounds is a Department of Biology, 2Department of Physics, College of Science, University of Duhok, 1006 AJ Duhok, Kurdistan Region, Iraq. Address for correspondence: [email protected]. Haval Y. Yacoob Aldosky
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serious problem because it delays healing and increases scarring, while invasive infection can lead to a fatal outcome [2]. Patients with severe burn injuries are at high risk of developing hospital-associated infections that are the most common cause of death [5]. Dramatic decline in the development of novel antibiotic agents over the past 30 years coincided with the increase in antibiotic resistance, making the situation worse. Therefore, to address this challenge, effective strategies are required. Some examples of these strategies are combination therapy, the use of nanomaterials and magnetic nanoparticles [4], and improvement of surgical treatment. Alternative therapies aimed at minimization of mul
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