Aminaphtone in the control of Schamberg's disease
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BioMed Central
Open Access
Case report
Aminaphtone in the control of Schamberg's disease José Maria Pereira de Godoy*1 and Fernando Batigália2 Address: 1Angiology and Vascular Surgery Service, São José do Rio Preto Medicine School, SP (FAMERP), Brazil and 2São José do Rio Preto Medicine School, SP (FAMERP), Brazil Email: José Maria Pereira de Godoy* - [email protected]; Fernando Batigália - [email protected] * Corresponding author
Published: 11 June 2009 Thrombosis Journal 2009, 7:8
doi:10.1186/1477-9560-7-8
Received: 22 February 2009 Accepted: 11 June 2009
This article is available from: http://www.thrombosisjournal.com/content/7/1/8 © 2009 de Godoy and Batigália; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract The aim of this case report is to describe control of Schamberg's disease using aminaphtone. We report on the case of a 28-year-old patient who presented with multiple purpuric lesions of the lower extremities which had appeared spontaneously. A biopsy of the skin was performed that showed a perivascular T-cell lymphocytic infiltrate centered on the small superficial blood vessels of the skin and so a diagnosis of Schamberg's disease was reached. The patient was prescribed corticoids and the lesions disappeared however on suspension of the medication the lesions reemerged within three to seven days. This treatment was unsuccessfully continued for more than one year. Thus another therapeutic option was attempted: 75 mg of aminaphtone was prescribed twice daily for one month and the purpuric lesions disappeared within about one week. One year after suspending the medication no relapse of the purpura was observed.
Introduction Since progressive pigmented purpuric dermatitis, also known as Schamberg's disease, was first described in 1901, several articles have appeared that have dealt largely with clinical and histologic features of the illness[1]. The lesions may occur in any location but most often affect the lower extremities. The skin lesions are nonpalpable macules, which are typically asymptomatic, may persist for months to years; normally only the aesthetic appearance is of concern to patients [2]. Histologic examinations show a lymphocytic vasculitis involving the blood vessels of the upper dermis with endothelial swelling and extravasated red blood cells[3]. Several therapies have been used including topical and systemic corticosteroids, vitamin C and topical and systemic anti-inflammatory agents[4]. As aminaphtone has been used to treat patients with changes in capillary per-
meability and fragility[5,6], it may be useful in the control of Schamberg's disease. The aim of this case report is to describe the treatment of Schamberg's disease using aminaphtone.
Case report We report on the case of a 28-year-old patient who
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