The influence of CYP1A1 and CYP1A2 polymorphisms on stroke risk in the Chinese population
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RESEARCH
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The influence of CYP1A1 and CYP1A2 polymorphisms on stroke risk in the Chinese population Yan Mao1, Lin Yang2, Qian Chen1, Guoqing Li3, Yao Sun3, Jiamin Wu3, Zichao Xiong3, Yuanwei Liu3, Haiyue Li3, Jianfeng Liu3 and Yong Zhang4*
Abstract Backgrounds: Stroke is a sudden disorder of cerebral blood circulation. Many studies have illustrated that dyslipidemia, hypertension, diabetes, smoking and excessive drinking are the traditional risk factors for stroke. This study aimed to observe the relationship between CYP1A1 and CYP1A2 variants and stroke risk in the Chinese population. Methods: Agena MassARRAY Assay was used to genotype four single nucleotide polymorphisms (SNPs) in 477 cases and 480 controls. The chi-square test and logistic-regression analysis were used to explore the relationship between CYP1A1 and CYP1A2 variants and stroke risk. Results: Individuals with CYP1A2 rs762551 C was associated with a lower risk of stroke than that of allele A. Age stratification analysis showed that rs762551 was only observed to be associated with a lower risk of stroke in ≤64ys age group. After gender stratification analysis, a significant association between rs762551 and stroke risk was found in males, but not in females. The four SNPs were found to be correlated with stroke risk in patients with hypertension, coronary heart disease, cerebral infarction and lacunar infarction. Conclusion: In this study, the results first showed that CYP1A1 and CYP1A2 variants were associated with stroke risk. Larger and well-designed studies are needed to confirm the results. Keywords: Population study, Chinese, Stroke, CYP1A1, CYP1A2, Polymorphisms
Background Generally speaking, stroke is a sudden disorder of cerebral blood circulation in the brain that occurs when blood clot blocks arteries transmitting blood from heart to brain [1]. At present, it ranks as the second leading cause of death in the world and the main cause of adult disability and death in most developing and developed countries [2]. According to the World Health Organization report in 2019, 5.5 million people died of stroke [3]. In China, there are over 2 million stroke patients and 6–7 million stroke * Correspondence: [email protected] 4 The Second Department of Encephalopathy, Baoji Hospital of Traditional Chinese Medicine, Baoji 721001, Shaanxi, China Full list of author information is available at the end of the article
survivors every year [4]. About 80% of stroke patients are ischemic [5, 6]. Many studies illustrated that dyslipidemia, hypertension, diabetes, smoking and excessive drinking are the traditional risk factors for stroke [7]. Moreover, genetic factors are also involved in stroke risk assessment. Cytochrome P450s (CYPs) is a widely distributed oxyhemoglobin superfamily, whose main function is to activate the molecular oxygen of lipophilic organic compounds, including drugs, steroids, fatty acids, bioamines, prostaglandins, plant metabolites, estradiol, estrone, etc. [8]. Some of these compounds are carcinogens, but most of th
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