An immunohistochemical study of canine spontaneous gastric polyps
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An immunohistochemical study of canine spontaneous gastric polyps Irina Amorim1,2†, Marian A Taulescu3†, Andreia Ferreira1,4, Alexandra Rêma1, Celso A Reis1,2,5, Augusto M Faustino1, Cornel Cătoi3 and Fátima Gärtner1,2*
Abstract Background: Gastric polyps (GP) are characterised by luminal overgrowths projecting above the plane of the mucosal surface that can be classified as non-neoplastic and neoplastic lesions. In humans, recent studies have drawn attention to the malignant potential of some of these lesions. However, gastric polyps are uncommon lesions in dogs. Findings: In this study, the presence of Helicobacter spp., the cellular proliferative activity, potential phenotypic alterations, COX-2 and p53 expression in canine spontaneous gastric polyps were investigated. The expression of these molecules was also studied in normal canine gastric mucosa in order to gain further knowledge of the significance of their loss or overexpression in gastric lesions. Conclusions: The normal expression of almost all the factors evaluated, along with the reduced proliferative activity is strongly suggestive that, in dogs, spontaneous gastric polyps are not only a rare finding but also of benign nature. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/ 13000_2014_166 Keywords: Canine gastric polyps, COX-2, CDX2, Helicobacter spp, Ki67, p53
Introduction Gastric polyps (GPs) are considered a heterogeneous entity broadly defined as luminal lesions projecting above the plane of the mucosal surface that can be biologically classified as non-neoplastic and neoplastic lesions. In humans, further classification relies on the evaluation of the histogenesis and neoplastic potential of these lesions [1]. Accordingly, among the non-neoplastic epithelial gastric polyps, three subtypes are recognized: fundic gland polyps; hyperplastic polyps (and variants) and neuroendocrine tumours (NET). Fundic gland polyps represent the most common type and they are histologically characterized by cistically dilated fundic-type glands lined by flattened parietal cells with a degree of architectural distortion. The surface comprises foveolar type epithelium, which may appear * Correspondence: [email protected] † Equal contributors 1 Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Rua Jorge Viterbo Ferreira nr.228, 4050-313 Porto, Portugal 2 Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Rua Dr. Roberto Frias s/n, 4200-465 Porto, Portugal Full list of author information is available at the end of the article
atrophic [1]. The hyperplastic polyps are typically observed in the antrum and histologically consist in hyperplastic, elongated and branching foveolae set in an abundant oedematous and inflamed stroma. Cystic dilation of the pits is almost invariable present in the deeper portions and surface is lined by a single-layer of foveolar-type epithelium [1]. Hyperplastic polyps occur agains
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