An Update on Antitumor Activity of Angelica Species
Genus Angelica (Family: Apiaceae) comprises more than 60 species of medicinal plants. Many of these species have long been used in ancient traditional medicine systems, especially in the Eastern countries. For many years, several species of Angelica, e.g.
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An Update on Antitumor Activity of Angelica Species Amira Mira and Kuniyoshi Shimizu
Abstract Genus Angelica (Family: Apiaceae) comprises more than 60 species of medicinal plants. Many of these species have long been used in ancient traditional medicine systems, especially in the Eastern countries. For many years, several species of Angelica, e.g., A. archangelica, A. dahurica, A. keiskei, A. gigas, A. pubescens, A. sinensis, A. shikokiana have been used traditionally as anti-inflammatory, diuretic, expectorant, and diaphoretic. Also, these have been used as remedies for hepatitis, arthritis, indigestion, coughs, chronic bronchitis, pleurisy, fever, rheumatism, bacterial and fungal infections, and diseases of the urinary organs. Several classes of compounds such as coumarins, acetylenic compounds, chalcones, sesquiterpenes, and polysaccharides have been reported from these plants. This chapter outlines the results of various scientific studies on Angelica species that were reported to have anticancer and antitumor activities. Keywords Angelica • Antitumor • Chalcones • Coumarins
Abbreviations ALT AME Chk2 DDY DMBA GBM GGT
Alanine transaminase A. shikokiana methanol extract Checkpoint kinase 2 Deutschland, Denken, and Yoken mice 7,12-Dimethylbenz[a]anthracene Glioblastoma multiforme Gamma-glutamyl transpeptidase
A. Mira Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt K. Shimizu (*) Division of Systematic Forest and Forest Products Sciences, Department of AgroEnvironmental Sciences, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka 812-8581, Japan e-mail: [email protected] © Springer Science+Business Media Singapore 2016 H.-S. Tsay et al. (eds.), Medicinal Plants - Recent Advances in Research and Development, DOI 10.1007/978-981-10-1085-9_15
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HCC HDAC8 iNOS MMP-9 NO PANC-1 PKC RES TAA TNF TPA VEGF-C
15.1
Hepatocellular carcinoma Histone deacetylase 8 Inducible nitric oxide synthase Matrix metalloproteinase 9 Nitric oxide Human pancreas cancer cell line Protein kinase C Reticuloendothelial system Thioacetamide Tumor necrosis factor 12-O-Tetradecanoylphorbol-13-acetate Vascular endothelial growth factor C
Introduction
The genus Angelica L. belongs to the family Apiaceae (alt. Umbelliferae). It comprises more than 60 species of medicinally important biennial or perennial herbs (Martin and Hutchins 1980). Plants of this genus are widely distributed in Asia, Europe, and North America. Angelica is one of the most important genera of medicinal plants that are still in use in both traditional medicine systems of the Far East and the Western countries (Sarker and Nahar 2004). To date, several phytochemical and pharmacological studies resulted in the discovery of a number of active compounds from certain species of Angelica. The scientific studies reported the antitumor effectiveness of some of the isolated compounds either singled or in combination with known antitumor compounds (Jung et al. 2014). A previous r
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