Mechanisms of Oncogenesis An update on Tumorigenesis
This volume is part of a book series that was first published in 10-volumes by Kluwer in 1989 under the series editorship of Professor Hans E. Kaiser, D.Sc., former Professor of Pathology at the School of Medicine, University of Maryland at Baltimore, MD,
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Cancer Growth and Progression Volume 12 Founding Editor Hans E. Kaiser† , D. Sc. Series Editors Aejaz Nasir, M.D., M. Phil., FCAP Department of Interdisciplinary Oncology-Pathology, Moffit Cancer Center & Research Institute, Tampa, FL, U.S.A. Timothy J. Yeatman, M.D. Professor of Surgery, Executive Vice President Translational Research, President & Chief Scientific Officer M2Gen, Moffit Cancer Center & Research Institute, Tampa, FL, USA
For further volumes: http://www.springer.com/series/5721
Mechanisms of Oncogenesis An Update on Tumorigenesis
Edited by Domenico Coppola Moffitt Cancer Center, Tampa, FL, USA
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Editor Prof. Domenico Coppola H. Lee Moffitt Cancer Center & Research Institute 12902 Magnolia Drive Tampa FL 33612 USA [email protected]
ISBN 978-90-481-3724-4 e-ISBN 978-90-481-3725-1 DOI 10.1007/978-90-481-3725-1 Springer Dordrecht Heidelberg London New York Library of Congress Control Number: 2010922896 © Springer Science+Business Media B.V. 2010 No part of this work may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording or otherwise, without written permission from the Publisher, with the exception of any material supplied specifically for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. Printed on acid-free paper Springer is part of Springer Science+Business Media (www.springer.com)
Preface
This volume is a continuation of the encyclopedic work entitled “Cancer Growth and Progression,” that was originally edited by Professor Hans E. Kaiser. As a tribute to the memory of Dr. Kaiser and his contributions to the field, this new edition is following his example of providing the most current information about cancer literature and comprehensive coverage of all aspects of tumor growth and progression. This particular tome is divided into two sections: the first addressing general causes of oncogenesis such as environmental factors and tumor mechanisms; and the second addressing the oncogenic mechanisms of tumor in specific organs. This book is written and compiled by world renowned leaders in their respective fields and focuses on the most recent developments in basic oncogenesis. This definitive text will provide the practitioner, whether in research, academia or clinical practice, with a fount of easily accessible information on the most common tumors.
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Contents
1 Cytokines and Stressors: Implications for Cancer Immunotherapy Alexander W. Kusnecov and Hymie Anisman
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2 The Role of Oncogene Activation in Tumor Progression . . . . . . . Michael J. Gray and Gary E. Gallick
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3 Carcinogenic Effects of Ionising Radiation . . . . . . . . . . . . . . Arthur C. Upton
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4 Chemical Carcinogenesis Role of Chloroform – Further Studies . . Elizabeth K. Weisburger
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5 Use of Organ Explant and Cell Culture in Cancer Research . . . . Eric J. Kort, Christine R. Moore, Eric A. Hudson, Brandon Leeser, James H. Resau, G.M. Yer
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