Analyses of expressions and prognostic values of Polo-like kinases in non-small cell lung cancer
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ORIGINAL ARTICLE – CANCER RESEARCH
Analyses of expressions and prognostic values of Polo‑like kinases in non‑small cell lung cancer Yu Zeng1,3 · Nanhong Li2,4 · Wang Liu1 · Mingqing Zeng5 · Junfen Cheng1 · Jian Huang2,4 Received: 9 March 2020 / Accepted: 9 June 2020 © Springer-Verlag GmbH Germany, part of Springer Nature 2020
Abstract Background Despite great advances in its early diagnosis and treatment, lung cancer is still an intractable disease and the second leading cause of cancer-related deaths and morbidity in the world. The family of Polo-like kinases (PLKs) consists of five serine/threonine kinases, which have been reported to participate in various human diseases. However, the expression and prognostic value of each PLK in human lung cancer have not been fully understood. This study analyzed mRNA expression and prognostic value of different PLKs in human non-small cell lung cancer (NSCLC). Methods First, mRNA expression of PLKs in patients with NSCLC from the Oncomine and the Gene Expression Profiling Interactive Analysis (GEPIA) database was investigated. Then, a Kaplan–Meier plotter was employed for survival analysis. The sequence alteration for PLKs was analyzed using The Cancer Genome Atlas (TCGA) and the cBioPortal database. Additionally, we analyzed the association among different PLKs using the LinkedOmics database. Finally, the enrichment analysis of PLKs was achieved using the DAVID database. Results The mRNA expression levels of PLK1 and PLK4 were significantly overexpressed, while mRNA expression level of PLK3 was underexpressed in patients with NSCLC. mRNA expressions of PLK1 and PLK4 were significantly and positively related to the tumor stage of NSCLC. Increased expressions of PLK1, PLK4, and PLK5 and decreased expression of PLK2 were attributed to limited overall survival time in NSCLC. PLK1 was positively correlated with PLK4 via the LinkedOmics database. Conclusions PLKs are relevant targets for NSCLC treatment, especially PLK1 and PLK4. Keywords Lung cancer · Polo-like kinases · Prognosis · Oncomine · Kaplan–Meier plotter
Introduction Lung cancer is an intractable disease and the second leading cause of cancer-related deaths and morbidity (Siegel et al. 2019). The main pathological subtypes of lung cancer Yu Zeng and Nanhong Li contributed equally to this work. * Junfen Cheng [email protected] * Jian Huang [email protected] 1
2
Department of Respiration, The Second Affiliated Hospital of Guangdong Medical University, 12# Minyou Road, Xiashan, Zhanjiang 524003, Guangdong, People’s Republic of China Pathological Diagnosis and Research Center, Affiliated Hospital, Guangdong Medical University, 57# Renmin avenue South, Xiashan, Zhanjiang 524000, Guangdong, People’s Republic of China
3
Graduate School, Guangdong Medical University, 2# Wenming Eastern Road, Xiashan, Zhanjiang 524023, Guangdong, People’s Republic of China
4
Department of Pathology, Guangdong Medical University, 2# Wenming Eastern Road, Xiashan, Zhanjiang 524023, Guangdong, People’s Republic of Ch
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